Business Systems Maintenance Lead

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do

Let’s do this. Let’s change the world. We are seeking a Business Systems Maintenance Lead to join our digital and sourcing technology team as an Information Systems Manager. This individual will be responsible for managing and coordinating the organization’s information systems operations, overseeing deployments, and ensuring continuous improvement of digital tools. The role will require strong technical expertise, project management capabilities, and a passion for driving operational efficiency. This leader will play a critical role in supporting ERP and niche source-to-contract (S2C) systems, maintaining stability and performance, and enabling innovation through special projects such as GenAI implementations.

Roles & Responsibilities

Systems Operations & Maintenance

• Oversee day-to-day management of enterprise ERP and S2C platforms.

• Coordinate with IT teams and vendors to ensure uptime, stability, and resilience of business systems.

• Manage and optimize the ticketing system for incident resolution, request management, and service-level performance.

• Conduct scheduled maintenance, upgrades, and patch deployments while minimizing business disruption.

Project Management & Delivery

• Lead special projects such as GenAI implementation, automation pilots, and new tool deployments.

• Develop detailed project plans, manage budgets, and track milestones.

• Ensure cross-functional alignment with procurement, finance, and IT.

Process Improvement & Operational Efficiency

• Identify opportunities to streamline system workflows and reduce manual workload.

• Partner with business stakeholders to implement process enhancements within ERP and S2C environments.

• Ensure systems deliver measurable value through efficiency gains and compliance readiness.

Governance, Compliance & Audit Readiness

• Ensure systems and processes comply with SOX, GxP, GDPR, and internal audit standards.

• Maintain complete documentation of upgrades, configurations, and workflows for inspection readiness.

• Implement robust role-based access controls and data governance practices.

Stakeholder Engagement & Enablement

• Act as the bridge between IT, procurement, finance, and system users.

• Facilitate training, adoption, and communications for new features and system changes.

• Develop user-friendly knowledge bases, playbooks, and SOPs.

Vendor & Contract Management

• Manage vendor relationships, performance dashboards, and SLA adherence.

• Coordinate with providers for timely patches, updates, and support escalations.

Team Leadership & Mentorship

• Mentor junior analysts and administrators on system workflows, governance, and ticketing best practices.

• Build a culture of accountability, service orientation, and innovation.

Functional Skills

Must-Have Skills

• Strong technical knowledge of ERP systems (SAP, Oracle, etc.) and niche S2C platforms (Ariba, Ivalua, SirionLabs, etc.).

• Hands-on experience with system maintenance, upgrades, and integrations.

• Proficiency in ticketing systems (ServiceNow, Jira, or similar).

• Proven ability to manage projects with budgets, milestones, and cross-functional stakeholders.

• Knowledge of regulatory compliance requirements (SOX, GxP, GDPR).

Good-to-Have Skills

• Familiarity with GenAI applications and automation technologies.

• Experience with APIs and middleware integrations.

• Exposure to change management practices and user adoption strategies.

• ITIL, Agile, or PMP certifications.

Soft Skills

• Communication & Influence: Ability to clearly communicate system changes and their impacts to diverse stakeholders.

• Strategic Thinking: Vision to evolve systems for scalability, security, and efficiency.

• Collaboration: Strong cross-functional collaboration skills with IT, procurement, and finance.

• Adaptability: Flexibility to manage priorities in dynamic, high-stakes environments.

• Problem Solving: Structured problem-solving approach to address system and process challenges.

• Attention to Detail: Precision in handling system configurations, compliance documentation, and performance reporting.