Senior Infrastructure Systems Engineer

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched Guardant360®, Guardant360 CDx, Guardant360 TissueNext™, Guardant360 Response™, and GuardantOMNI® tests for advanced stage cancer patients, and Guardant Reveal™ for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield™ test, aims to address the needs of individuals eligible for cancer screening.

Position Title: Senior Infrastructure Systems Engineer

Location: Hyderabad, India

Job Type: Full-Time

Position Overview:

Guardant Health is seeking a Senior Infrastructure Systems Engineer to develop, manage and support our enterprise virtualization and Linux infrastructure. This role focuses on VMware, Linux systems, enterprise storage, and automation, playing a key part in delivering reliable and scalable platforms for mission-critical operations.

Key Responsibilities:

• Design, configure, and support Linux systems (RHEL, Oracle Linux, Ubuntu) on virtual and physical platforms.
• Manage filesystems, LVM, partitions, mount points, and performance tuning.
• Perform OS patching with Red Hat Satellite, Ubuntu Landscape, or similar tools.
• Automate tasks using Ansible, Terraform, Bash, or Python.
• Implement/maintain authentication/identity configurations using Kerberos and SSSD.
• Troubleshoot complex OS, storage, and networking issues.
• Architect and operate VMware infrastructure (vSphere, ESXi, vCenter, vSAN, NSX).
• Manage Horizon VDI pools, connection servers, and end-user experience.
• Integrate and optimize PURE Storage for VMware workloads.
• Administer backup and recovery using Rubrik and Pure Storage snapshots.
• Monitor infrastructure health and plan for capacity and DR readiness.
• Support hybrid workloads in AWS, including EC2 and storage services.
• Work with container platforms such as Docker and Kubernetes.

Qualifications:

• Bachelor's in computer science, Engineering, or equivalent experience.
• 8+ years in Linux systems engineering (RHEL, Oracle Linux, Ubuntu).
• 5+ years in VMware administration, including Horizon VDI.
• Strong knowledge of LVM, ext4, xfs, tuning, and partitioning.
• Experience with PURE Storage, Rubrik, and enterprise backup strategies.
• Proficiency in Bash, Python, Ansible, Terraform.
• Familiarity with monitoring tools and technologies (Zabbix, Prometheus, Nagios)
• AWS and container platform experience required.

Preferred Qualifications:

• VMware VCP-DCV / VCP-DTM.
• Red Hat Certified Engineer (RHCE), Oracle Linux certifications.
• Exposure to CI/CD pipelines, Infrastructure as Code (IaC) practices.
• Experience with AWS Outposts is a strong plus.

Why Join Us:

At Guardant Health, you'll help build and support infrastructure that powers cutting-edge cancer diagnostics. You’ll work with modern technologies, collaborate with global teams, and contribute directly to projects that make a difference in patient care. This is your opportunity to grow your expertise while supporting a mission that matters

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Please visit our career page at: http://www.guardanthealth.com/jobs/