Senior Cloud Engineer – AWS High Performance Computing (Clinical Pharmacology Domain)

Experience- 7-12 years

Location- Pune / Noida / Hyderabad / Bengaluru / Chennai

JD-

Position Overview:

We are seeking a Senior Cloud Engineer with deep expertise in AWS-based High-Performance Computing (HPC) and proven experience supporting Clinical Pharmacology and Pharmacometrics workloads. The incumbent will lead the design, deployment, and optimization of large-scale, secure, and compliant HPC infrastructures on AWS, enabling high-performance modeling, simulation, and computational research for global R&D teams.

Key Responsibilities:

• Architect, design, and lead implementation of HPC environments on AWS optimized for pharmacometric modeling, simulation, and data-intensive scientific workloads.
• Define and implement HPC architecture standards, cost optimization strategies, and scaling patterns across compute, storage, and data pipelines.
• Partner with Clinical Pharmacology, Pharmacometrics, and R&D IT stakeholders to translate scientific computing requirements into robust cloud solutions.
• Automate and orchestrate complex workloads for tools such as Phoenix WinNonlin, Pirana, Monolix, NONMEM, and MATLAB using AWS-native and open-source technologies.
• Lead development of Infrastructure-as-Code (IaC) frameworks using Terraform or AWS CloudFormation for reproducible and auditable infrastructure provisioning.
• Drive CI/CD pipeline implementation for model execution and environment deployment.
• Ensure adherence to 21 CFR Part 11, GxP, and organizational data security and compliance standards.
• Provide technical mentorship to junior engineers and guide cross-functional teams in best practices for HPC workload management and cloud optimization.
• Conduct performance benchmarking, cost analysis, and scalability assessments to continuously improve HPC infrastructure.

Required Technical Skills:

• Cloud Platforms: Expert-level proficiency in AWS (EC2, Batch, ParallelCluster, FSx, S3, CloudFormation, Lambda).
• High Performance Computing: HPC cluster architecture, scheduling (SLURM / AWS Batch), parallel and distributed computing, containerization (Docker, Singularity).
• Infrastructure-as-Code (IaC): Terraform, AWS CloudFormation.
• Scripting & Automation: Advanced skills in Python, Bash, and PowerShell.
• DevOps & CI/CD: Jenkins, GitHub Actions, or similar tools for automating environment deployment.
• OS & Networking: Linux (RHEL/Ubuntu), IAM, VPC design, network security, VPN, and hybrid connectivity (Direct Connect).
• Monitoring & Optimization: AWS CloudWatch, CloudTrail, Cost Explorer, and cost governance best practices.
• Data Storage: Experience with S3 lifecycle management, FSx for Lustre, EFS, and data caching strategies for HPC workloads.
• Experience integrating and supporting modeling and simulation tools — Phoenix WinNonlin, Pirana, Monolix, NONMEM, MATLAB.
• Understanding of clinical data standards (CDISC, SDTM, ADaM) and workflows in Clinical Pharmacology / Pharmacometrics.
• Familiarity with data visualization and analytics tools (Spotfire, R Shiny, Tableau).
• Experience with workflow management systems (Nextflow, Airflow, Snakemake).
• Exposure to container orchestration (Kubernetes / AWS EKS).
• Prior experience in a regulated life sciences IT or pharmaceutical R&D computing environment.

Domain Experience (Mandatory):

• In-depth understanding of Clinical Pharmacology and Pharmacometrics workflows, including PK/PD modeling, parameter estimation, and simulation processes.
• Experience collaborating with scientists and modelers to support computational R&D workloads in a regulated environment.

Education:

• Bachelor’s or Master’s degree in Computer Science, Computational Sciences, or a related field.
• Additional certifications in Clinical Pharmacology, AWS Certifications: AWS Certified Solutions Architect – Professional or AWS Certified Advanced Networking – Specialty.

Job Types: Full-time, Permanent

Pay: From ₹1,500,000.00 per year

Application Question(s):

• How many years of experience do you have in AWS-based High-Performance Computing (HPC)?
• How many years of experience do you have in Clinical Pharmacology Domain?
• How many years of experience do you have in AWS (EC2, Batch, ParallelCluster, FSx, S3, CloudFormation, Lambda)?
• How many years of experience do you have in modeling and simulation tools — Phoenix WinNonlin, Pirana, Monolix, NONMEM, MATLAB?
• Have you applied or attended the interview in Birlasoft in last 6 months?
• What is your current CTC?
• What is your expected CTC?
• What is your notice period/ LWD?
• What is you current and preferred location?
• Are you ok with third-party payroll?
• How many years of total experience do you currently have?