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Job Title: Principal Scientist – Cell-Based Assay Team Lead (Antibody Characterization)Location: InfoPark Kochi, Kerala, IndiaPosition Type: Full-time, PermanentCompany: Simisco Biologics,Application Deadline: May 23 rd , 2025Start Date: Negotiable About Us:Simisco Biologics is a biotherapeutics company developing innovative protein engineeringsolutions to problems in oncology, infectious and regenerative diseases. We build on a 20+ yearhistory of experience, infrastructure and relationships in therapeutic antibody development andthrive on collaboration, creativity, and a passion for translating scientific discoveries into life-saving treatments. Position Summary: We are seeking a highly motivated and experienced Principal Scientist to lead a dynamic teamof 5–10 scientists in the design and execution of cell-based assays to evaluate the functionalproperties of novel therapeutic antibodies. The ideal candidate will bring extensive expertise inmammalian cell biology, receptor tyrosine kinases (RTKs), and antibody science, coupled withhands-on experience in phospho-western blotting, standard western blotting, cellularproliferation assays, and cytotoxicity/killing assays.This leadership role is both strategic and hands-on, requiring a deep understanding of antibody-receptor interactions and their effects on cellular signaling and the ability to quickly interpret andtroubleshoot experimental results. The successful candidate will play a key role in advancingour therapeutic pipeline by developing robust assays and guiding the scientific direction of theteam. Key Responsibilities:  Lead, mentor, and manage a team of 5–10 scientists conducting cell-based assays toassess antibody function. Design, implement, and optimize assays such as phospho-western blots, standardwestern blots, proliferation assays, and killing/cytotoxicity assays. Drive characterization of antibody activity against receptor tyrosine kinases and othermammalian cell surface receptors. Analyze complex biological data, provide clear interpretation, and propose next steps. Collaborate cross-functionally with Protein Design, Protein Production, Flow Cytometryand Translational teams to align assay strategies with program goals. Contribute to equipment sourcing, project planning, resource allocation, and milestonetracking. Ensure rigorous documentation and data quality standards are maintained. Present findings to internal stakeholders and contribute to scientific publications andregulatory documents. Qualifications Ph.D. in Cell Biology, Immunology, Molecular Biology, or a related field with 5 years of relevantindustry experience; or M.S. with 10 years of directly applicable experience. Demonstrated expertise in cell signaling pathways, particularly receptor tyrosine kinasesand cell surface receptors. Strong background in antibody biology and recombinant protein function. Proven ability to develop, troubleshoot, and refine cell-based functional assays. Experience managing scientific teams and fostering collaborative, high-performanceenvironments. Excellent problem-solving, communication, and organizational skills. A track record of scientific innovation and impactful contributions to drug discovery ordevelopment. Preferred Qualifications:  Experience with high-throughput screening platforms or automated assay systems. Familiarity with flow cytometry, ELISA, or other complementary assay technologies. Prior work in oncology, immuno-oncology, or regenerative medicine areas.Why Simisco Biologics? Be part of an innovative and dynamic team at the forefront of scientific discovery Opportunities for career growth and advancement in a cutting-edge, collaborativeenvironment. Competitive salary, benefits, and the chance to contribute to life-saving therapies. To Apply:Please submit the following materials to minu.an@scigenom.com: A cover letter detailing your relevant experience and career goals CV including a list of publications Names and contact information for three professional references
