Senior Manager / Associate General Manager – Discovery Services

Job Title:

Senior Manager / Associate General Manager – Discovery Services

Location:

Department:

Reporting to:

About Enzene Biosciences

Enzene Biosciences Ltd.

automation, digital integration, and global compliance

Discovery Services division

Role Overview

phage and yeast display platforms

Key Responsibilities

• Lead and execute

  phage and yeast display

  discovery programs for antibody and peptide therapeutics.
• Design

  high-throughput screening strategies

  , selection protocols, and affinity maturation campaigns.
• Oversee

  library construction

  (naïve, synthetic, immune) and validation with appropriate QC measures.
• Drive

  characterization and ranking

  of hits using biophysical and biochemical techniques.
• Collaborate with internal teams including

  Protein Sciences, Bioinformatics, Preclinical, and Regulatory

  .
• Ensure project delivery against timelines, scientific objectives, and regulatory quality expectations.
• Supervise and mentor a team of scientists and research associates, fostering scientific growth.
• Support generation of

  technical documentation, presentations, IP filings, and regulatory dossiers

  .
• Stay abreast of emerging display technologies, industry trends, and peer-reviewed advancements.

Required Qualifications

• PhD in

  Biotechnology, Immunology, Protein Engineering, Molecular Biology

  , or related field.
• 8–12 years of experience in the biotech/pharma industry or academia (including postdoctoral work).
• Proven expertise in

  phage and/or yeast display

  , including library design, selection, and optimization.
• Strong command of

  antibody structure-function

  , epitope mapping, and affinity maturation principles.
• Proficiency in molecular biology (cloning, expression), protein purification, ELISA/SPR/BLI, and FACS.
• Experience leading research programs and cross-functional teams.
• Familiarity with the

  biologics development pipeline

  , including regulatory expectations, is preferred.
• Strong communication, project management, and scientific documentation skills.

Preferred Skills

• Exposure to

  next-generation sequencing (NGS)

  for library diversity analysis.
• Familiarity with

  computational antibody design

  or structural modeling tools.
• Knowledge of alternative display systems (e.g.,

  mammalian display

  , hybrid formats).
• Track record of scientific

  publications, patents, or conference presentations

  in relevant fields.

Why Join Enzene?

• Opportunity to lead

  innovative discovery programs

  in a global-scale biologics environment
• Work with cutting-edge

  platform technologies

  in antibody engineering and screening
• Collaborate with

  world-class scientific and operational teams

  in a rapidly growing biotech company
• Competitive compensation, supportive culture, and strong scientific leadership