AGM/DGM- Biotech R&D/ Manufacturing

Key Responsibilities:

Technical & Operational Responsibilities:

• Lead end-to-end upstream fermentation operations including

  media preparation, seed culture development, fermentation scale-up

  , and harvest.
• Optimize classical microbial fermentation processes for high cell density and metabolite production using bacteria, yeast, or fungi (e.g., E. coli, Bacillus, Saccharomyces, Streptomyces).
• Ensure production targets (volume, yield, quality, and timelines) are consistently achieved.
• Troubleshoot upstream process deviations, contamination, or yield drops.
• Collaborate with R&D and Tech Transfer teams for

  scale-up and commercial execution

  of new strains or processes.
• Evaluate and implement

  process improvements

  , automation, and cost-saving initiatives.
• Review and ensure accurate documentation (batch records, SOPs, deviation reports, change controls).

Compliance & Quality:

• Ensure operations are in full compliance with

  cGMP, regulatory, and EHS

  requirements.
• Support

  regulatory audits

  (USFDA, EMA, WHO, etc.) and customer inspections.
• Participate in investigations (OOS/OOT, deviations) and implement CAPAs related to upstream activities.

Team Leadership & Coordination:

• Lead, mentor, and develop a team of production officers, operators, and shift engineers.
• Ensure adequate training of team members on fermentation operations and GMP.
• Coordinate closely with downstream, QA, maintenance, and warehouse functions for smooth operations.

jai.mirchandani@symbiotec.in