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Scientist/Manager-Upstream Process Development (Cell culture)

Scientist/Manager-Upstream Process Development (Cell culture)

Mynvax

7 - 12 years

1 - 50 Lacs

bengaluru

Posted:3 hours ago| Platform:

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Skills Required

head business development minitab process optimization project management analytical scheduling glp life sciences gmp troubleshooting

Work Mode

Work from Office

Job Type

Full Time

Job Description

Mynvax is a biotechnology company focused on the discovery, development, and scalable manufacturing of thermostable recombinant vaccines against respiratory and emerging viral infections. The company collaborates closely with leading academic and translational partners including the Indian Institute of Science, THSTI, and global R&D groups.

Role

Lead upstream process development for recombinant protein and vaccine antigen production using insect (Sf9, Sf21) & mammalian (CHO) cells.
Plan, design, and execute experiments for media/feed optimization, infection/transfection kinetics, and process scale-up (1-50 L).
Supervise and mentor a team of 4-5 Research Associates/Senior Research Associates to ensure smooth lab and pilot-scale operations.
Ensure adherence to aseptic and cleanroom practices, GLP/GMP guidelines, and biosafety regulations.
Review and approve experimental protocols, batch records, and process documentation.
Collaborate cross-functionally with downstream, analytical, and QA/QC teams for process integration and technology transfer.
Participate in troubleshooting, root cause analysis, and CAPA implementation for upstream-related deviations.
Prepare detailed technical reports, development summaries, and contribute to regulatory documentation and IND/IMPD filings.
Drive innovation in upstream process optimization using statistical design tools (DoE), PAT, and bioreactor data analytics.
Plan resource utilization, equipment scheduling, and inventory management for the upstream lab.

Required Qualifications and skills

Ph.D. or MTech/M.Sc. in Biotechnology, Biochemical Engineering, or related life sciences discipline.
7-12 years of industrial experience in cell culture-based process development and scale-up for recombinant proteins or vaccines.
Strong hands-on experience with insect cell culture (baculovirus/Sf9 systems) and mammalian cell lines (CHO).
Experience operating and optimizing bioreactors (1-50 L) and familiarity with bioreactor control systems (Applikon, Sartorius, etc.).
Proven ability to lead and mentor teams in a fast-paced R&D environment.
Excellent understanding of aseptic techniques, bioprocess scale-up, and upstream-downstream process interfaces.
Strong project management, documentation, and presentation skills.
Ability to independently plan, execute, and deliver on project timelines.

Desirable Skills

Exposure to GMP manufacturing or tech transfer environments.
Experience with statistical design tools (DoE, JMP, Minitab) and PAT implementation.
Knowledge of vaccine development workflows and regulatory documentation requirements (IND/IMPD).
Familiarity with continuous processing or high-cell-density culture systems.

Reporting to

Head-Preclinical R&D

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Scientist/Manager-Upstream Process Development (Cell culture)