Experienced Medicinal Chemist

experienced medicinal chemist

Key Responsibilities

• Design, plan, and execute synthetic routes to support iterative compound design and structure-activity relationship (SAR) studies.
• Analyze and prioritize screening hits based on potency, selectivity, and chemical tractability.
• Apply biophysical and biochemical assay data (e.g., SPR, NMR, IC₅₀) to assess compound binding and refine structures.
• Collaborate with computational chemists for structure-guided drug design, virtual screening, and docking studies.
• Optimize compounds for multiple parameters including potency, solubility, selectivity, metabolic stability, and pharmacokinetic properties.
• Incorporate early ADME and safety profiling data (e.g., microsomal stability, permeability, CYP inhibition) into lead selection decisions.
• Troubleshoot synthetic challenges and improve efficiency in compound production and purification.
• Work cross-functionally with biology, DMPK, and pharmacology teams to support candidate advancement.
• Maintain accurate records, contribute to project meetings, and present experimental findings and SAR rationale.

Required Qualifications

• Ph.D. or M.Sc. in Organic or Medicinal Chemistry with 

  5+ years

   of relevant experience in small-molecule drug discovery.
• Demonstrated expertise in synthetic organic chemistry and medicinal chemistry principles.
• Strong understanding of DMTA cycles and hands-on experience in SAR-driven lead development.
• Proficiency with analytical tools (NMR, LC-MS, HPLC) and compound characterization techniques.
• Effective collaboration in multidisciplinary project teams and clear scientific communication.