KenisLabs

We are looking for an experienced medicinal chemist with hands-on expertise in small-molecule drug discovery. This role involves driving the design, synthesis, and optimization of chemical compounds from early hit identification through to lead optimization. The ideal candidate will bring strong experimental chemistry capabilities, SAR insight, and cross-functional collaboration skills to advance high-quality drug candidates. Key Responsibilities Design, plan, and execute synthetic routes to support iterative compound design and structure-activity relationship (SAR) studies. Analyze and prioritize screening hits based on potency, selectivity, and chemical tractability. Apply biophysical and biochemical assay data (e.g., SPR, NMR, IC₅₀) to assess compound binding and refine structures. Collaborate with computational chemists for structure-guided drug design, virtual screening, and docking studies. Optimize compounds for multiple parameters including potency, solubility, selectivity, metabolic stability, and pharmacokinetic properties. Incorporate early ADME and safety profiling data (e.g., microsomal stability, permeability, CYP inhibition) into lead selection decisions. Troubleshoot synthetic challenges and improve efficiency in compound production and purification. Work cross-functionally with biology, DMPK, and pharmacology teams to support candidate advancement. Maintain accurate records, contribute to project meetings , and present experimental findings and SAR rationale. Required Qualifications Ph.D. or M.Sc. in Organic or Medicinal Chemistry with 5+ years of relevant experience in small-molecule drug discovery. Demonstrated expertise in synthetic organic chemistry and medicinal chemistry principles. Strong understanding of DMTA cycles and hands-on experience in SAR-driven lead development. Proficiency with analytical tools (NMR, LC-MS, HPLC) and compound characterization techniques. Effective collaboration in multidisciplinary project teams and clear scientific communication.