Technician

Department
BiologySalary£32,080 - £33,002 per yearGradeGrade 5Contract statusFixed termHours of workFull-timeBased atUniversity of York campusInterview dateTo be confirmedPosted Date05/09/2025Apply by19/09/2025Job Reference14373Documents

• Job Description (14373).pdf (PDF, 330.42kb)
  

Role DescriptionDepartmentBiology DepartmentUnderstanding how GSK3β controls neuronal development and maintenance in time and spaceGSK-3β is a key player during the formation and maintenance of neurons. Over-activity has been linked to various neurodevelopmental and -degenerative diseases (e.g. Alzheimer's and Parkinson's Disease, autism spectrum and mood disorders) making it a highly promising therapeutic drug target. So far, therapeutic strategies manipulating GSK-3β have failed because their application was too general. In this project, we will pioneer the development of novel biosensors to explore GSK-3β activation and localised targeting of GSK-3β activity to study exactly when and where GSK-3β has to be active to influence neuronal development, and which regulators mediate this. Gaining this refined understanding of GSK-3β will provide the foundations for improved therapeutic strategies. This project is funded by a grant to Dr Ines Hahn (York), Dr Han-Jou Chen and Dr Peter O’Toole from BBSRC.RoleA description of the main duties and responsibilities of the job, as stated in the main purpose of the role and relevant key responsibilities in the job template (6-8 lines).The appointee will work in an active research lab, with other neuroscience groups including technicians and research students all working on a range of neurodegenerative problems. They will provide technical and scientific support to a research project in a neuronal cell biology research laboratory, use molecular biology approaches to generate locally targeted GSK-3β variants, perform experiments using Drosophila primary neurons and maintain and generate Drosophila lines.

Skills, Experience & Qualification Needed

• Details of the main qualifications, knowledge, skills, experience and qualifications essential to the post (as stated in the 'person specification’ in the job template)
  

Interview date: To be confirmed
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