Associate Scientist

Upstream Process Development Scientist

Upstream Process Development Scientist

Responsibilities

• Design, execute, and analyze experiments for the development and optimization of upstream cell culture processes, focusing on CHO cell lines.
• Work with large molecules, including monoclonal antibodies (mAbs) and biosimilars, throughout the process development lifecycle.
• Operate and troubleshoot various bioreactor systems, including AMBR250, Single-Use Bioreactors (SUBs), and 10L reactors.
• Optimize cell culture media, feeding strategies, and process parameters to maximize yield and product quality.
• Analyze process data, interpret results, and present findings to the team.
• Contribute to the transfer of developed processes to manufacturing.
• Maintain detailed and accurate documentation of all experimental work.
• Stay current with industry trends and advancements in upstream process development.
  

Qualifications

• Master's in Chemical Engineering, Biotechnology, Bioengineering, or a related scientific discipline.
• 2-5 years of hands-on experience in upstream process development within the biopharmaceutical industry.
• Demonstrated expertise in handling and culturing CHO cells.
• Proven experience with large molecule production, specifically monoclonal antibodies (mAbs) and biosimilars.
• Hands-on experience operating and troubleshooting AMBR250, Single-Use Bioreactors (SUBs), and 10L reactors.
• Strong understanding of cell culture principles, bioreactor operations, and process scale-up.
• Excellent data analysis, troubleshooting, and problem-solving skills.
• Ability to work independently and collaboratively in a fast-paced environment.
• Strong written and verbal communication skills.
  

Bonus Points If You Have

• Experience with Design of Experiments (DoE) software and statistical analysis.
• Knowledge of GMP principles and regulatory guidelines