40 Api Synthesis Jobs

We are looking for a meticulous and driven R&D Chemist to contribute to innovative API (Active Pharmaceutical Ingredient) synthesis at Synnat Pharma Private Limited. As an integral part of our expanding R&D team in Visakhapatnam, you will be instrumental in executing experiments, maintaining detailed records, and ensuring the safe operation of laboratory equipment. Your responsibilities will encompass handling R&D equipment, performing experiments according to established procedures, and meticulously documenting observations. You will also manage sample submissions for both internal and external analysis, while adhering to stringent quality and safety standards. The ideal candidate will possess a strong foundation in analytical chemistry, coupled with practical experience in pharmaceutical R&D. This role demands proficiency in data analysis, a commitment to data integrity, and familiarity with raw material indent processes. If you are passionate about contributing to the advancement of pharmaceutical development and thrive in a collaborative environment, we encourage you to apply. Responsibilities: Conduct and document R&D experiments, noting deviations. Maintain R&D records, ensuring data integrity and traceability per Synnat Pharma policies. Analyze experimental data to identify trends and contribute to conclusions. Utilize ChemDraw for API chemical structure and reaction scheme design. Operate and maintain R&D equipment (stirrers, rotovaps, hydrogenators), performing maintenance and troubleshooting. Prepare and submit samples for analytical testing (NMR, Mass Spec), tracking status and communicating results. Prepare raw material indents and follow up on orders. Maintain raw material inventory, monitoring expiration dates and resolving availability issues. Prepare reports and presentations summarizing experimental findings. Adhere to Synnat Pharma's safety protocols, maintaining a clean and organized lab. Report safety incidents and participate in safety training. Analyze analytical results, compare with expected values, and communicate discrepancies. General Expectations and Past Experiences: Proven ability to handle R&D equipment and perform experiments according to established procedures with 1-3 years of experience. Strong understanding of analytical chemistry principles and techniques, with proficiency in data analysis and interpretation. Demonstrated experience in sample submission processes, including coordination with analytical teams and follow-up on results. Familiarity with raw material indent procedures, including preparing indents, tracking orders, and managing inventory. Excellent attention to detail and commitment to data integrity, ensuring the accuracy and reliability of research findings. Proficiency in using ChemDraw software for chemical structure drawing and reaction scheme design. Adherence to safety protocols and a proactive approach to maintaining a safe and organized laboratory environment.

Hiring Quality Assurance Officer with 1 to 3 year experience. Should have sound knowledge of Production of Pharma/chemical industry Documenting and keeping records and assisting QA team for in depth analysis. Handling preventive action Required Candidate profile Review of Risk Assessment & investigation report. Should be Bsc in organic chemistry. nearby western line mumbai candidates will be preferred upto Boisar,Tarapur,Palghar district. Male candidates

Role & responsibilities R&D Synthesis: Experience in API synthesis, process development, and DMF filing. Develop cost-effective, high-quality, and eco-friendly processes as per ICH guidelines. Optimize lab processes, validate products, and transfer technology to pilot plant. Design and propose specifications for KSM, intermediates, and APIs. Proficient in NMR, Mass, IR characterization and troubleshooting synthesis/impurity issues. Prepare documentation for process development and technology transfer.

Hiring for Principal Scientist for a leading Pharma MNC at Pune. Role & responsibilities Reporting to : Associate Director Job Summary : To develop synthesis processes of highly potent and/or cytotoxic ADC drug-linkers and transfer processes to internal/external clients and collaborate with manufacturing teams to deliver robust chemical processes that are suitable for commercial-scale manufacturing, while ensuring safety and regulatory compliance. Key Responsibilities: 1. Detailed technical evaluation of project enquiries received from the customers/ BD team. 2. Literature search, scouting the appropriate routes, and Drug-linker process optimization. 3. Execution of Bioconjugation Chemistry in lab and GMP manufacturing on Lab scale. 4. Collaborating with synthetic/analytical chemists, bioconjugation scientists, biologics development team, engineers, PM, DQA, IPMG, BD, PE/TT, manufacturing units, and regulatory teams to develop and support the commercialization of ADCs. 5. Support for kilo lab batches and during commercial campaigns to achieve the QOTIF. 6. To help grow the ADC teams capabilities, research facilities, and enhance the ADC's portfolio. 7. Thorough drug-linker process development and support regulatory submissions, often with compressed timelines. 8. When appropriate, mentor, train, and supervise junior team members in this role. 9. Help drive internal facilities growth to support highly potent and/or cytotoxic material handling. 10. Manage multiple projects and/or material deliveries simultaneously. 11. Monitor and implement safety in the laboratory. 12. Troubleshoots technical challenges during scale-up & tech transfer, monitors schedules, and manages documentation in line with GMP guidelines. Preferred candidate profile Required Qualifications and Experience: MSc organic chemistry with 13+ years of relevant industrial experience in the process development/optimization of ADCs or PhD/post-doctorate in synthetic organic chemistry with experience in ADC drug-linkers. Key Competencies: Problem solving. Conflict resolution. Decision making. Communication skills. Leadership. Negotiation. Collaboration. Cross-functional collaboration. Technical Skills: Proficient in using MS Office. Knowledge of ADCs, Knowledge of High-potent API, Knowledge of working in GMP set-up, organic/process chemistry & safety API process development, tech transfer & manufacturing, proficient analytical skills for small as well as large molecules. to apply please share Resumes with Puja.k@maxisclinical.com Regards Puja

Walk-In Drive For API Research & Development(R&D)- Venue Details : MSN Laboratories Pvt. Ltd, R&D Centre, Pashamylaram (V), Patancheru (M), Sangareddy (D.t), Telangana on Saturday 06-09-2025 . Department : API R&D Designation : Executive / Sr. Executive / Jr Manager Experience : 1- 10 Years Qualification : M.Sc. Organic Chemistry Work Location : MSN R&D Center, Pashamylaram, Hyderabad Work Location : MSN R&D Center, Pashamylaram, Hyderabad Interview Venue Details : Venue Details : MSN Laboratories Pvt. Ltd, R&D Centre, Pashamylaram (V), Patancheru (M), Sangareddy (D.t), Telangana on Saturday 30-08-2025 ..

Role & responsibilities Experience in operation and trouble shooting of process in plant. Isolation and purification of different organic compound using column chromatographic and crystallization techniques. Optimize the process parameters, what-if studies, holding studies etc. for scale up. Investigation of OOS/OOT and stability related issues. Handled various reagents like NaH, NaBH4, Br2, BHA, n-BuLi,TMSCl, TFA,PPA, Raney Nickel, Pd/carbon & also hazardous chemicals like POCl3, SOCl2 etc. Reactions performed like Hydrogenation,Brominaion,Oxidation,Reduction and condensation. Handling of Moisture sensitive reactions. Study and understand the project requirements, identifying and collection of suitable literature. Support lab manager to prepare weekly technical reports and other project related technical documents (impurity profile tables,Plant batch data,developmental reports) Executing assigned reactions of project. • Looking after the Safety equipments management and maintaining it as per regulatory requirement in R&D lab. • Study the MSDS of each chemical using in every new project and make arrangement of Safety equipments accordingly. Handled HPLC system of Agilent technologies Ezichrome (A.04.07) and version Open Lab cds2.4 • Good in Thin layer chromatography & Column chromatography. Preferred candidate profile Perks and benefits

Roles and Responsibilities Develop new APIs through organic synthesis, method development, and optimization. Conduct literature reviews to stay updated on latest research trends and technologies. Ensure compliance with GMP guidelines during API manufacturing processes. Collaborate with cross-functional teams for product development, scale-up, and commercialization. Perform impurity analysis using techniques like NMR, DSC, etc. Desired Candidate Profile MS/M.Sc(Science) degree in Chemistry or Ph.D/Doctorate in Chemical Sciences from a recognized university. Strong expertise in areas such as API synthesis, organic chemistry, method development/validation/transfer/methodology. 9-14 years of experience in Research & Development (R&D) or related field. Key Responsibilities Literature Review & Route Identification Perform comprehensive literature and patent searches (SciFinder, Reaxys, PubChem, etc.). Identify and evaluate synthetic routes for APIs, intermediates, and impurities. Synthetic Research & Development Plan and perform multi-step organic synthesis experiments. Develop and optimize cost-effective and robust synthetic processes. Work on impurity profiling and synthesis of known/unknown impurities (including nitrosamines/nitroamines). Process Optimization & Scale-Up Support Optimize reaction parameters for higher yield, purity, and reproducibility. Support process development, kilo-lab trials, and technology transfer. Address scale-up challenges in collaboration with process R&D teams. Analytical Collaboration Interpret analytical data (HPLC, LC-MS, NMR, IR) for structure confirmation. Work with Analytical R&D to characterize intermediates, APIs, and impurities. Documentation & Compliance Maintain accurate lab notebooks, experiment records, and reports. Prepare technical documents for DMFs, ANDAs, and regulatory submissions. Ensure GLP, GMP, EHS, and data integrity compliance. Teamwork & Leadership (For Sr. Executive Level) Independently lead assigned projects with minimal supervision. Mentor and guide junior chemists/trainees in lab activities. Provide technical support for regulatory/customer queries.

Job Description: Preparation & Standard Solution and its standardization Product literature search Carrying out R & D experiment & maintaining record and report to higher authority Analysis method development of new products

Role & responsibilities Process Development: Conduct research and design experiments to develop and optimize synthetic routes for API molecules. Perform literature searches for identified API molecules to determine synthesis routes, polymorphs, and analytical methods. Conduct experimental trials to assess feasibility and optimize designed synthetic routes for API molecules. Documentation: Record all experiments in the laboratory notebook (LNB) and maintain corresponding analytical data in organized folders. Design synthetic routes for the synthesis and isolation of impurities and reference standards. Ensure all documentation meets Good Manufacturing Practices (GMP) and regulatory standards. Safety and Compliance: Adhere to all safety protocols and ensure a safe working environment in the laboratory. Develop non-infringing synthetic processes based on literature, raw material availability, and polymorph studies. Stay up-to-date with industry trends, regulatory guidelines, and advancements in chemical synthesis and analytical techniques.Team Collaboration: Plan daily activities for team members, focusing on feasibility studies, process optimization, and laboratory validation. Work closely with the Analytical Research and Development (ARD) team on method development, in-process testing, and reference standards qualification. Qualifications: Education: MSc/BSc in Organic Chemistry, Experience: Fresher or 1-2 years experience in process development and optimization in the pharmaceutical or bulk drug industry. Skills: Strong knowledge of synthetic organic chemistry and process chemistry. Proficiency in using and interpreting data from analytical instruments. Excellent problem-solving skills and attention to detail. Effective communication and teamwork skills. Ability to work independently and manage multiple projects simultaneously. Preferred candidate profile We are looking for a talented and driven junior R&D Associate to join our team. The successful candidate will be responsible for developing and optimizing chemical processes for synthesizing active pharmaceutical ingredients (APIs). This role requires a strong background in synthetic organic chemistry, process development, and scale-up techniques. The R&D Chemist will collaborate with cross-functional teams to ensure the smooth transition of processes from the lab to full-scale production. Perks and benefits

Position Purpose : This position is responsible for daily overall functioning of the R & D laboratory, provide guidance perform experiments and prepare documentation for R & D and Pilot Plant. Role & Responsibilities: To Plan & perform Lab experiments for Process development as per Guideline To modify & optimise lab process for plant scale-up batches To keep record of all experiment taken To prepare & record the documents of R&D & Pilot plant batch work on day to day To execute and assist demo batches to plant chemist To Deliver the project/Product as per committed timeline To provide online support to production dept. for trouble shooting To look after glass wares, lab wares / instruments, calibration & maintenance. To Prepare the process write up with document team. To submit tech transfer document to QA along with PDR To follow the guideline and SOPs of R&D department To create healthy working atmosphere in R&D To train & guide trainee chemist Be always careful about chemical handling by following safety measures and also give training to juniors. To coordinate with ADL, Plant and maintenance. To take work as per allocation for officers and operators. To carry out literature search for better alternate safe process.

Position: Manager - Peptide Production Grade: G10 Job Location: Ahmednagar Qualification: M.Sc. (Chemistry) / B.E. (Chemical) / B.Tech (Chemical) Experience: 10-18 yrs experience in Peptide API plant Job Profile 1. To plan and execute peptide manufacturing activities as per the schedule and Budget by optimum utilization of plant capacity 2. To ensure the sustainable quality production with optimum utilization of plant capacity. 3. Monitoring and reduction in process TRT, Cleaning TRT, number of preps per batch on Prep HPLC, Improve yields. Improve the process of Synthesis & Analytical Section. 4. Co-ordinate with Purchase, Planning department to deliver the goods in time. 5. To ensure every day interaction with each department for smooth functioning 6. Compliance of waste water disposal as per IN-HOUSE policy 7. To ensure grooming of disciplined workforce and staff to meet the planned growth charts. 8. Developing different innovative practices to increase productivities and up gradation of work culture. 9. To maintain Good Documentation Practices and Good Laboratory Practices 10. Review of batch process record, Standard Operating procedure and cGMP documents 11. Investigation of Deviation, Change Control & OOS 12. Implementation & follow all safety instruction & practices

Literature review TLC monitoring Rotavap handling Column chromatography

As a Research Associate in the R&D department of Dishman Carbogen Amcis Limited, located in Bavla, Gujarat, India, you will be responsible for API synthesis in process development. Your role will involve contributing to research and development activities, focusing on the synthesis of active pharmaceutical ingredients (APIs) and process optimization. Your experience and expertise in R&D, particularly in API synthesis, will be crucial for the success of our Contract Research business unit. If you are a motivated individual with a background in R&D and a keen interest in research activities, this role offers you the opportunity to be part of a dynamic team dedicated to innovation and excellence. Your contributions will directly impact the development of new pharmaceutical products and processes, making a significant difference in the healthcare industry. Join us in our mission to advance pharmaceutical research and development, and be a key player in shaping the future of healthcare. Apply now and take the next step in your career as a Research Associate in our R&D department at Dishman Carbogen Amcis Limited.,

Greetings!!! We are seeking for a API - Research & Development Synthesis role for a Pharma Manufacturing Company at Chennai . Role & responsibilities: Develop and optimize synthetic routes for APIs and intermediates. Conduct lab-scale experiments and process development for scale-up. Perform literature surveys and impurity profiling. Interpret analytical data (NMR, HPLC, GC, IR) for structural confirmation. Prepare development reports and support tech transfer to kilo/pilot plant. Ensure compliance with GMP, EHS, and regulatory requirements. Collaborate with cross-functional teams (QA/QC, Regulatory, Manufacturing). Maintain accurate documentation for regulatory submissions (DMF, ANDA, etc.). Interested Candidates kindly share your updated cv to srinidhi@bvrpc.com

Develop the scientific & strategic direction of the synthesis research business, overseeing drug discovery initiatives, managing research teams, ensuring the effective administration & growth. Required Candidate profile Ph.D. in Chemistry with 20+ years in CRO/ process development/synthesis with a strong flair of senior/top research leadership role would be an ideal fit. Willing to work at the lab and be a mentor. Perks and benefits Best of CTC, additional perks and benefits

Role & responsibilities Experience in the development of Generic APIs Development / improvement of the assigned products and overall review of development activities. To finalize route based on literature or feasibility of process or availability of raw materials. Technology transfer, scale-up and troubleshooting To provide required relevant information for regulatory filing and response to regulatory queries. To prepare and review documents Maintain the development records and overall review of given projects. To maintain records as per IMS requirements. Preferred candidate profile Must have experience in the development of Generic APIs

Role & responsibilities Expertise in carrying out Multi-step synthesis of organic molecules from milligram to multi-gram scales and their characterization. Responsible for the development efficient synthetic process, which leads to better yields and quality of the product, with less cycle time and cost. Capturing proper learning of the project & would be responsible for maintaining the confidentiality of the project as per the IPR guidelines. Scaling up of process and technology transfer from lab to plant and trouble shooting at the time of scale up. Interpretation of analytical reports like HPLC, GC, NMR, LCMS, IR, GCMS. Knowledge of designing route of synthesis for target molecule. Carried out experiments in laboratory and optimize process in terms of Regulatory Affairs (RA), Safety, cost and time effectiveness. Strong knowledge on process validation in laboratory and demonstration in plants. Adept at preparing documents like Technology transfer document (TTD), Process development report (PDR), presentations and reports for review meetings. Process validation and optimization with QBD. Preparing documents like Solubility chart, Material balance, Green card, Hold time study, Details of process, MSD. Literature search .through Sci-finder and Reaxys Ability to handle linear and parallel multi-step organic synthesis Experienced with purification techniques like thin layer & column chromatography, Crystallization and distillations. Structural elucidation through NMR (1H, 13C), IR, Mass (LC/MS, GC/MS). Good Co ordination with Cross functional teams as well as team mates. Accurate record keeping in laboratory notebook (LNB) and (ELN).

Job description Key Responsibilities: • Conduct organic synthesis experiments to develop and optimize routes for API synthesis. • Design and execute experiments to scale-up synthesis processes from laboratory to pilot plant scale. • Analyze and interpret experimental data to draw conclusions and make recommendations for process improvements. • Collaborate with cross-functional teams including process development, analytical chemistry, and manufacturing to support project objectives. • Maintain accurate records of experimental procedures, observations, and results in accordance with regulatory guidelines. • Stay updated with relevant scientific literature and contribute to the intellectual property portfolio of the company through patent filings and publications. Interested candidates forward resume on anuverma@scllifesciences.com or Whats app/ call on 9988339860.

Role & responsibilities Process Development: Conduct research and design experiments to develop and optimize synthetic routes for API molecules. Perform literature searches for identified API molecules to determine synthesis routes, polymorphs, and analytical methods. Conduct experimental trials to assess feasibility and optimize designed synthetic routes for API molecules. Documentation: Record all experiments in the laboratory notebook (LNB) and maintain corresponding analytical data in organized folders. Design synthetic routes for the synthesis and isolation of impurities and reference standards. Ensure all documentation meets Good Manufacturing Practices (GMP) and regulatory standards. Safety and Compliance: Adhere to all safety protocols and ensure a safe working environment in the laboratory. Develop non-infringing synthetic processes based on literature, raw material availability, and polymorph studies. Stay up-to-date with industry trends, regulatory guidelines, and advancements in chemical synthesis and analytical techniques.Team Collaboration: Plan daily activities for team members, focusing on feasibility studies, process optimization, and laboratory validation. Work closely with the Analytical Research and Development (ARD) team on method development, in-process testing, and reference standards qualification. Qualifications: Education: MSc/BSc in Organic Chemistry, Experience: Minimum of 3-5 years of experience in process development and optimization in the pharmaceutical or bulk drug industry. Skills: Strong knowledge of synthetic organic chemistry and process chemistry. Proficiency in using and interpreting data from analytical instruments. Excellent problem-solving skills and attention to detail. EZective communication and teamwork skills. Ability to work independently and manage multiple projects simultaneously. Preferred candidate profile We are looking for a talented and driven R&D Chemist to join our team. The successful candidate will be responsible for developing and optimizing chemical processes for synthesizing active pharmaceutical ingredients (APIs). This role requires a strong background in synthetic organic chemistry, process development, and scale-up techniques. The R&D Chemist will collaborate with cross-functional teams to ensure the smooth transition of processes from the lab to full-scale production. Perks and benefits

Role & responsibilities Process Development: Conduct research and design experiments to develop and optimize synthetic routes for API molecules. Perform literature searches for identified API molecules to determine synthesis routes, polymorphs, and analytical methods. Conduct experimental trials to assess feasibility and optimize designed synthetic routes for API molecules. Documentation: Record all experiments in the laboratory notebook (LNB) and maintain corresponding analytical data in organized folders. Design synthetic routes for the synthesis and isolation of impurities and reference standards. Ensure all documentation meets Good Manufacturing Practices (GMP) and regulatory standards. Safety and Compliance: Adhere to all safety protocols and ensure a safe working environment in the laboratory. Develop non-infringing synthetic processes based on literature, raw material availability, and polymorph studies. Stay up-to-date with industry trends, regulatory guidelines, and advancements in chemical synthesis and analytical techniques.Team Collaboration: Plan daily activities for team members, focusing on feasibility studies, process optimization, and laboratory validation. Work closely with the Analytical Research and Development (ARD) team on method development, in-process testing, and reference standards qualification. Qualifications: Education: MSc/BSc in Organic Chemistry, Experience: Fresher or 1-2 years experience in process development and optimization in the pharmaceutical or bulk drug industry. Skills: Strong knowledge of synthetic organic chemistry and process chemistry. Proficiency in using and interpreting data from analytical instruments. Excellent problem-solving skills and attention to detail. Effective communication and teamwork skills. Ability to work independently and manage multiple projects simultaneously. Preferred candidate profile We are looking for a talented and driven junior R&D Associate to join our team. The successful candidate will be responsible for developing and optimizing chemical processes for synthesizing active pharmaceutical ingredients (APIs). This role requires a strong background in synthetic organic chemistry, process development, and scale-up techniques. The R&D Chemist will collaborate with cross-functional teams to ensure the smooth transition of processes from the lab to full-scale production. Perks and benefits

Responsibilities: * Develop processes through lab validation * Conduct R&D synthesis with API focus * Collaborate on miscellaneous industry projects * Ensure compliance with safety standards Annual bonus Provident fund Office cab/shuttle

The ideal candidate will be responsible for optimizing API synthesis processes to enhance yield, and quality. Executing experiments to develop novel synthetic routes for APIs, applying principles of organic chemistry and process engineering. Collaboration with cross-functional teams, such as process chemists, analytical chemists, and chemical engineers, will be essential for the development and scale-up of API manufacturing processes. Candidates should possess strong analytical interpretation skills, including proficiency in NMR, MASS, IR, HPLC, and GC techniques. Good communication skills and knowledge of GLP/GMP guidelines are required. Flow chemistry experience is preferred. Preferred candidate profile M.Sc with 3 - 4 Years of experience

Key Responsibilities Conduct synthesis and process development experiments under the guidance of R&D scientists. Health insurance Provident fund

Research Associate Candidate should be experienced in process development in R&D in API synthesis Technology transfer, scale-up and troubleshooting of Lab developed process at Pilot and Commercial level. To carry experimental work for development / improvement of the products assigned. To carry out any job assigned by immediate supervisor / HOD Analytical Associate Well conversant with operating, handling and troubleshooting in HPLC, GC To maintain analytical records as per IMS. Co-ordinate with ADL dept. / Q.C dept. for method development activity. Development or improvement of methods for the assigned project Desired Profile: M.Sc. - Organic Chemistry/Analytical Chemistry Experience: 02 - 07 years Must be having experience in API

Research Associate Candidate should be experienced in process development in R&D in API synthesis Technology transfer, scale-up and troubleshooting of Lab developed process at Pilot and Commercial level. To carry experimental work for development / improvement of the products assigned. To carry out any job assigned by immediate supervisor / HOD Analytical Associate Well conversant with operating, handling and troubleshooting in HPLC, GC To maintain analytical records as per IMS. Co-ordinate with ADL dept. / Q.C dept. for method development activity. Development or improvement of methods for the assigned project Desired Profile: M.Sc. - Organic Chemistry/Analytical Chemistry Experience: 02 - 07 years Must be having experience in API