18 Dmpk Jobs

As a Medicinal Chemistry leader at Alembic, you will be at the forefront of driving the next wave of therapeutic innovation. Your role will involve shaping the future of drug discovery from India and bridging into the U.S. biotech ecosystem. Based in Hyderabad Genome Valley, you will work full-time and report to the Head of Drug Discovery at Alembic. You will be tasked with spearheading small-molecule and peptide drug discovery efforts, shaping and executing innovative strategies that drive programs from target identification to nominating clinical candidates. Alembic is seeking a visionary and accomplished leader with a track record of advancing compounds from early discovery to IND-enabling studies. The ideal candidate will possess deep expertise in medicinal chemistry, hands-on problem-solving skills, and preferably experience in computational chemistry or AI-enabled design. Your key responsibilities will include leading medicinal chemistry strategies for designing, synthesizing, and optimizing novel drug candidates. You will execute SAR strategies to enhance potency, selectivity, and overall drug-like properties, driving hit-to-lead and lead optimization efforts across multiple discovery programs. Additionally, you will incorporate AI-driven drug design and computational modeling into the medicinal chemistry workflow and manage external collaborations with CROs and academic partners. Furthermore, you will partner closely with various teams such as biology, pharmacology, DMPK, and analytical chemistry to integrate data and advance candidates efficiently. Your role will also involve analyzing experimental results, generating hypotheses, and making data-driven decisions to guide programs. Building and mentoring a team of medicinal chemists to foster scientific innovation and professional growth will also be a part of your responsibilities. To qualify for this role, you should hold a PhD in Organic or Medicinal Chemistry (or a related discipline) with over 10 years of industry experience in drug discovery. Demonstrated leadership in advancing small molecules or peptides into the clinic, deep expertise in synthetic chemistry, drug design, and SAR optimization are essential. Exposure to AI-based drug discovery, computational chemistry, or fragment-based design will be advantageous. Strong communication, leadership, and decision-making skills are also required. By joining Alembic, you will lead cutting-edge medicinal chemistry initiatives, collaborate with world-class scientists in an innovation-driven culture, play a central role in shaping Alembic's emerging therapeutic pipeline, and contribute to an organization committed to scientific rigor, global impact, and patient health. Alembic embraces diversity and is dedicated to building an inclusive team.,

Roles in DMPK we are hiring for : Bioanalytical / Peptides, Antibody drug conjugates and ASOs In vitro ADME / cell biology, cell permeability hepatocytes, 3D cultures, image analysis, drug transporters and enzymology PK/PD, Modeling and Simulations / Pheonix WinNonlin, R, Monolix, NONMEM, MATLAB, or any other custom-built software In vitro Toxicology/ 3D cultures-Organoids and Spheroids Key Responsibilities : Knowledge of data compilation and interpretation for test compound classification systems, either as substrates or uptake inhibitors. Ability to understand and read data, identify data variability, and participate in data review cycles with the QA team. Commitment to delivering data within agreed timelines (Less 7 days) and strong work ethics to complete assigned tasks. Excellent communication and collaboration skills, working closely with team members. Good oral and written communication skills. Education and Experience: M Pharm (Pharmacology/Pharmaceutics) with 3-8 years of experience or MSc with 6-8+ years of experience in DMPK of small molecule drug discovery and development, preferably in a CRO or Biotech/Pharma industry. Knowledge of FDA and EMA industry guidance

You get to collaborate on: Work closely with discovery specialists, disease area scientists and in vivo team members. Handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes and small animals surgery (like cannulations, CSF fluid collection) and handling, followed by compound dose preparation, administration to experimental animals. Contributing to the ongoing drug discovery programs by conducting in vivo DMPK studies for NCEs with a good knowledge of in vivo animal models. Data generation, analysis, compilation, report preparation. Regular uploading of the data. Conduct statistically supported data (analysis using win online) and deliver results in a timely manner to enable informed decision-making Understanding systems, processes, and compliance. Prepare, review, and deliver scientific presentations for internal/external use. Participate in cross-functional team activities, add value to research projects through creative ideas. Learn from top-notch drug discovery scientists across the world and opportunity to get trained in people skills. PK-PD studies in rat and mice of NCE.

Your key responsibilities will include conducting In Vitro ADME studies This involves reading and understanding various in vitro ADME protocols, as well as performing in vitro stability experiments for new chemical entities in liver microsomes, plasma, and other relevant matrices You will also conduct specific in vitro ADME experiments such as logP, logD, pKa measurements, CYP induction and inhibition assays, permeability determinations, CYP phenotyping, and solubility determinations in various cell lines In addition to in vitro ADME studies, you will be involved in bioanalysis activities This includes developing and validating LC-MS/MS and HPLC-UV/PDA methods, conducting bioanalytical QC, and handling bioanalytical method development for various matrices with a focus on in vitro samples Experience in developing LC-MS/MS methods for biochemical and cell-based screening of NCEs is a plus You will also be responsible for general LC-MS/MS and HPLC maintenance and troubleshooting tasks Furthermore, as part of your role, you will be required to analyze data, generate reports, and share them with the line manager This involves understanding the quality of bioanalytical data, conducting data analysis using software like Phoenix WinNonLin, calculating in vitro results/parameters using Excel spreadsheets, and generating reports in Excel, Word, and PowerPoint formats You will also be responsible for generating reports in both GLP and non-GLP formats based on the requirements

You get to collaborate on: Work closely with discovery specialists, disease area scientists and in vivo team members. Handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes and small animals surgery (like cannulations, CSF fluid collection) and handling, followed by compound dose preparation, administration to experimental animals. Contributing to the ongoing drug discovery programs by conducting in vivo DMPK studies for NCEs with a good knowledge of in vivo animal models. Data generation, analysis, compilation, report preparation. Regular uploading of the data. Conduct statistically supported data (analysis using win online) and deliver results in a timely manner to enable informed decision-making Understanding systems, processes, and compliance. Prepare, review, and deliver scientific presentations for internal/external use. Participate in cross-functional team activities, add value to research projects through creative ideas. Learn from top-notch drug discovery scientists across the world and opportunity to get trained in people skills. PK-PD studies in rat and mice of NCE.

Role & responsibilities Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Preferred candidate profile A M Pharm. in pharmaceutical sciences or M SC in biological science with nine or more years of Industrial experience in DMPK/ADME research.

Role & responsibilities Experience Minimum 3-5 years of experience in handling ADME assays and HPLC and LCMS/MS Skills and Capabilities Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff General understanding of Drug metabolism and Pharmacokinetics Should be able to deliver scientific presentation in departmental journal club and write official Project reports Preferred candidate profile M. Pharm in Pharmaceutical sciences, Pharmaceutical Analysis who has interest and passion for LC/MS related bioanalysis.

Job Title: Invitro BA Scientist Job Location: Bangalore, Hyderabad' About Syngene : Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit Mandatory expectation for all roles as per Syngene safety guidelines • Overall adherence to safe practices and procedures of oneself and the teams aligned • Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards • Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. • Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. • Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self • Compliance to Syngene s quality standards at all times • Hold self and their teams accountable for the achievement of safety goals • Govern and Review safety metrics from time to time Core Purpose of the Role : • To participate in sample processing for PK, ADME assays and handling of LCMS/MS. Ability to adapt to the dynamic team environment • Processing of different matrices samples of PK studies • Optimization of test compounds manually as well as automated on LCMS/MS • Develop methods with the team lead • Independently handling of HPLC for UV based samples analysis. • Documenting the lab note books online and compound management Syngene Values All employees will consistently demonstrate alignment with our core values ' Excellence Integrity Professionalism Experience 3- 10+years Education : Msc/Pharm/Mtech/Phd/ Fresh phd with relevant exp during academics or any postdoc Skills and Capabilities • Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory • Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods • Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis • Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required • Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra • Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff • General understanding of Drug metabolism and Pharmacokinetics • Should be able to deliver scientific presentation in departmental journal club and write official Project reports

Exciting Opportunity Alert - DMPK Roles at Syngene International! Are you passionate about drug discovery and eager to contribute to cutting-edge pharmaceutical research? Join us at Syngene International for the following roles: - ADME Scientist: MSc with 6-9 years or MPharma/Mtech with 3-6 years - Sr AS: MSc with 9-12 years, MPharm/Mtech with 6-9 years - Team Lead: Fresh PhD or MSc with 15-16 years, MPharma with 12-15 years - Sr Team Lead: PhD with 3-5 years of experience - Group Lead: PhD with 5-10 years - Senior Group Lead: PhD with 10+ years Fresh PhD candidates with relevant experience during academics or postdoc are also welcome. Key Skills Required: DMPK In vitro BA and In vitro ADME Kindly note that there are no current requirements for "In vivo BA" and "In vivo PK" positions. Please share your resumes at: Sulake.Divyasree@Syngeneintl.com Core Purpose of the Role: Lead the team of bioanalysts responsible for delivering high quality data for requested ADME studies withing agreed timelines Expertise in automated discovery bioanalysis workflow practices for both small and large molecules and new drug modalities like Protacs, ADCs, Oligonucleotides etc. Updated with the latest innovations in high throughput bioanalysis, both at instruments levels and data management Sound understanding of DMPK principles and have mandatory experience in handling global clients Comprehend outcome of various in-vitro/in-vivo assays and contribute to integrated drug discovery Projects as DMPK representative

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. : Medicinal chemistry; Research and development; Literature search; Scifinder / Reaxys; Design and synthesis; combiflash/Biotage; C-C coupling etc Qualifications MSC - Organic Chemistry.

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. Job description: Planning/performing and reporting of acute toxicology studies Assist in preparation of SOP"™s, Protocols and Reports Participate in GLP / AAALAC related activities Literature search Maintenance of animal house and relevant documents as per GLP and AAALAC norms. To Assist and work along with SD and TC in Planning, initiation and conduct studies. Test item administration, dose formulation preparation and blood collection. Assistance in data collection, compilation and verification. Participate in GLP inspections and ensure relevant regulatory compliance guidelines. Support in interpretation and reporting of study data. Assist in report preparation and coordination of activities. Assist in archiving of all study related materials. Skills Required: Understanding of the agrochemical and pharmaceutical R&D process Behavioral Competencies: Good in oral / written communication skills. If you're interested in applying or learning more, send your updated resume to [email protected] with the subject line "Research Scientist/Senior Research Scientist - Acute "“ Toxicology - Bangalore". Qualifications Qualification M.Sc. in Zoology/Biosciences Additional Information Specialization Toxicology Department Acute "“ Toxicology Experience (years) 2 to 8 only

Preferred candidate profile M. Pharm (Pharmacology) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 6-9 years or Ph.D. with 2-5 years' experience in PBPK & PK/PD modelling & Gastro plus; Simcyp software Role & responsibilities Experience in the development and application of pharmacometric models to support drug development and regulatory submissions Extensive experience with non-linear mixed effects modelling Proficient with software tools like PBPK models, Phoenix, R, PoPK, QSP modelling or similar platforms Strong background in pharmacokinetics/pharmacodynamics (PK/PD) modelling, First-in-human dose predictions. Collaborate with clinical pharmacology, biostatistics, and other interdisciplinary teams to inform clinical trial designs and data analysis Develop and implement model-based strategies to optimize dosing regimens and therapeutic outcomes Ensure the accuracy and quality of pharmacometric analyses and reports Engage with regulatory agencies and prepare regulatory submission documents related to pharmacometric analyses Stay abreast of the latest developments in pharmacometrics and incorporate new methodologies and technologies as appropriate Present findings and strategies to the project team meeting and cross-functional teams. Ability to work effectively in a team environment.

Preferred candidate profile M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry / Analytical Chemistry) with 3 - 6 years experience in Bioanalytical DMPK & Invivo PK. Role & responsibilities Planning and execution of invivo preclinical pharmacokinetic studies, invivo tissue distribution & mass balance studies in rodents. Expert in method development of NCEs using LC-MS/MS system Well verse with extraction techniques of molecules from various matrices like plasma/urine/tissues Experienced in surgical skills for rodents PK, excretion studies Conduct Bioanalysis of samples from in-vivo pharmacokinetic, tissue distribution studies, PK-PD & TK studies through LCMS/MS Prepare protocols and SOPs in line with industrys best practices Very strong in basics of all instruments, principles of chromatography, sample processing Knowledge of Phoenix WinNolin software will be added advantage

Preferred Candidate Profile: M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry / Analytical Chemistry) with 5-8 years or Ph.D. with 2-5 years experience. Role & responsibilities Experience in designing, performing, and interpreting metabolite identification studies- Invitro and Invivo. Proficient in using LC-MS/MS, HRMS, and other analytical techniques for identification of metabolites and its soft spots. Ability to analyze complex data sets and structural interpretation for Phase-1, 2, and 3 metabolites. Strong understanding of drug metabolism principles and pathway. Experience with regulatory documentation and submissions Experience in DMPK concepts and provide insights to project teams. Represent the group in internal and external meeting. Ability to work effectively in a team environment. Strong understanding of various concepts of DMPK in large molecule/ADC with excellent communication skills, driving innovation, managing teams is added advantage Responsible for preparation of relevant SOP, protocols, reports, etc. to support various regulatory and non-regulatory submission.

Role & responsibilities To perform in vitro ADME assays (solubility, metabolic and plasma stability, CYP inhibition, plasma protein binding studies etc.) Design, conduct and report data from in vitro metabolism studies using various cellular and subcellular systems, e.g., microsomes, hepatocytes, recombinant CYPs/UGTs and transfected cells. Perform assays using automated workstations. To design, program and implement study protocols in automated workstations. Ability to integrate metabolism and other supporting ADME data to predict druggability outcomes. To lead a group of 2-5 members and train juniors for the ongoing assays and technologies. Maintain labs & comply with SHE/regulatory guidelines. Preferred candidate profile Masters with 10+ years of PhD with 2+ years industry experience in Invitro ADME assays.

Hiring for Research Associate/ Sr. Research Associate for In- Vivo PK Studies -DMPK (Bangalore/Hyderabad Location) JOB DESCRIPTION Research Associate/ Senior Research Associate Department: Biology / DMPK Experience: 3-8 Years (In- Vivo PK studies) Key Responsibilities: Expert handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes like oral (p.o.), intravenous (i.v.), intraperitoneal (i.p.), subcutaneous (SC) etc. Cannulation of jugular vein, carotid artery, bile duct, portal vein and femoral vein in experimental rat model. Skilled in retro-orbital, Saphenous, Jugular bleeding, cardiac puncture, isolation of different organs of experimental animals after whole body perfusion. Flexibility, and the ability to work in fast paced and team-oriented environment. Should be able to calculate the dose and dose volume as per animal body weight. Knowledge of Determination of PK Parameters i.e. Cmax, Tmax, AUC, T1/2. Different types of PK: Plasma PK, Bile, Urine and Feces excretion, portal vein studies, CSF PK, Brain PK, Cassette PK, Snapshot PK etc Please share your CV if you have above skillset only " sanjana.tulasiram.c@aragen.com "

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. With over 30 years of GLP compliance and certification, Eurofins Advinus serves diverse industries such as Biotech, Pharmaceutical, Biological, Agrochemical, Nutraceutical and Cosmetic. Eurofins Advinus is the only contract research organization (CRO) in India to have developed data in support of 90+ end-to-end IND enabling packages to be submitted to global regulators such as USFDA, EMA, MHRA, Health Canada and others. Role to manage team size of 1 to 3 scientists (M.Sc.) Good team player, should be able to lead the team of 1-3 scientist (M.Sc.) and monitor their day-to-day activities along with his own to complete the time bound tasks Strong interpersonal skill and managing cross functional teams Sound knowledge in synthetic/Medicinal chemistry Niche area chemistry experience is preferred Performing fundamental literature & patent searches related to project activities and develop alternative strategies Sound knowledge of scientific search engine such as SciFinder, Reaxys etc. Sound knowledge of structural elucidation and interpretation using analytical techniques such as NMR, IR, HPLC, GC, LC-MS etc. Good knowledge of laboratory safety and be a strong promoter of SHE activities in the lab Qualifications For M.Sc, 7-10 years of Discovery/Medicinal Chemistry R&D experience and for PhD, 2-4 years of experience in discovery/medicinal Chemistry CRO. Additional Information Excellent technical, problem-solving, writing, influencing and communication skills Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude. Demonstrative communication skills and confident in conveying information to internal customer

Bioanalyst who will be responsible for high-quality discovery bioanalysis to support preclinical in vitro ADME and in vivo PK studies. LC-MS/MS based bioanalytical techniques to analyse biological samples in support of Drug Discovery projects. Required Candidate profile Around 5-8 years of experience in discovery bioanalysis to support in vitro ADME and pharmacokinetic studies.