25 Dmpk Jobs

M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 12-15 years or Ph.D. with 5 years experience Preferred candidate profile : Expert in designing and executing DMPK studies to support antibody-drug conjugate (ADC) and monoclonal antibody (mAb) programs, from discovery through IND-enabling stages. Extensive experience in quantification of biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS/MS, MSD, and ELISA platforms. Proficient in advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software. Skilled in applying innovative techniques for function-bas...

Role & responsibilities Roles and Responsibilities : Independently design, develop, validate, and troubleshoot bioanalytical methods for small and large molecules using LC-MS/MS and HPLC under GLP and non-GLP environments. Thorough understanding of bioanalytical method validation and sample analysis in biological matrices. Ability to lead junior team members, manage multiple projects , and interact with clients/regulatory bodies. Ensure efficient utilization of instruments and laboratory resources. Perform advanced operation, calibration, troubleshooting, and maintenance of LC-MS/MS , HPLC, and allied analytical equipment. Knowledge of international bioanalytical regulatory guidelines (USFDA...

Roles and Responsibilities : Responsible for drug metabolism and pharmacokinetic support for drug discovery programs. Develop and validate Bioanalytical method using LC-MSMS and other sophisticated instruments. Have a thorough knowledge of LC-MSMS, HPLC. Have knowledge of USFDA, MHRA, and M10 guidelines. Have excellent communication skills and the ability to co-ordinate with team members. Process good interpersonal and management skills. Strong basic knowledge of Operation, Calibration, and maintenance of laboratory equipment viz. Analytical balance, pH meter, centrifuge, Solid phase extraction unit and evaporator, and pipettes. Active involvement in method development of drug in In-vitro/In...

M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry / Analytical Chemistry) with 0 -1 years experience. Roles & Responsibilities: Strong in basics of DMPK domain and principles of chromatography as well as sample processing Planning and Execution of in-vivo preclinical pharmacokinetic studies, in-vivo tissue distribution & mass balance studies in rodents. Well verse with extraction techniques of molecules from various matrices like plasma/urine/tissues Conduct Bioanalysis of samples from in-vivo pharmacokinetic, tissue distribution studies, PK-PD & TK studies through LCMS/MS are added advantage Knowledge of Phoenix WinNolin software will be adde...

As a diligent team member, you will be responsible for following up with Buyers and End Users to obtain the import documents required for all Medchem, DMPK, and Biology shipments. Your role will also involve coordinating with Carriers/CHA on shipments documentation, ensuring accurate verification of shipment documents, obtaining checklist approvals, and sharing shipment documents with Stores for the shipment handover process. Additionally, you will be tasked with proactively following up with carriers and Brokers to ensure timely clearance of shipments and obtain the necessary post-shipping documents. Your attention to detail will be crucial in maintaining Management Information System (MIS)...

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. Job description: Planning/performing and reporting of acute toxicology studies Assist in preparation of SOP"™s, Protocols and Reports Participate in GLP / AAALAC related activities Literature search Maintenance of animal house and relevant documents as per GLP and AAALAC norms. To Assist and work along with SD and TC in Plann...

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. : Medicinal chemistry; Research and development; Literature search; Scifinder / Reaxys; Design and synthesis; combiflash/Biotage; C-C coupling etc Qualifications MSC - Organic Chemistry.

As a Medicinal Chemistry leader at Alembic, you will be at the forefront of driving the next wave of therapeutic innovation. Your role will involve shaping the future of drug discovery from India and bridging into the U.S. biotech ecosystem. Based in Hyderabad Genome Valley, you will work full-time and report to the Head of Drug Discovery at Alembic. You will be tasked with spearheading small-molecule and peptide drug discovery efforts, shaping and executing innovative strategies that drive programs from target identification to nominating clinical candidates. Alembic is seeking a visionary and accomplished leader with a track record of advancing compounds from early discovery to IND-enablin...

Roles in DMPK we are hiring for : Bioanalytical / Peptides, Antibody drug conjugates and ASOs In vitro ADME / cell biology, cell permeability hepatocytes, 3D cultures, image analysis, drug transporters and enzymology PK/PD, Modeling and Simulations / Pheonix WinNonlin, R, Monolix, NONMEM, MATLAB, or any other custom-built software In vitro Toxicology/ 3D cultures-Organoids and Spheroids Key Responsibilities : Knowledge of data compilation and interpretation for test compound classification systems, either as substrates or uptake inhibitors. Ability to understand and read data, identify data variability, and participate in data review cycles with the QA team. Commitment to delivering data wit...

You get to collaborate on: Work closely with discovery specialists, disease area scientists and in vivo team members. Handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes and small animals surgery (like cannulations, CSF fluid collection) and handling, followed by compound dose preparation, administration to experimental animals. Contributing to the ongoing drug discovery programs by conducting in vivo DMPK studies for NCEs with a good knowledge of in vivo animal models. Data generation, analysis, compilation, report preparation. Regular uploading of the data. Conduct statistically supported data (analysis usin...

Your key responsibilities will include conducting In Vitro ADME studies This involves reading and understanding various in vitro ADME protocols, as well as performing in vitro stability experiments for new chemical entities in liver microsomes, plasma, and other relevant matrices You will also conduct specific in vitro ADME experiments such as logP, logD, pKa measurements, CYP induction and inhibition assays, permeability determinations, CYP phenotyping, and solubility determinations in various cell lines In addition to in vitro ADME studies, you will be involved in bioanalysis activities This includes developing and validating LC-MS/MS and HPLC-UV/PDA methods, conducting bioanalytical QC, a...

You get to collaborate on: Work closely with discovery specialists, disease area scientists and in vivo team members. Handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes and small animals surgery (like cannulations, CSF fluid collection) and handling, followed by compound dose preparation, administration to experimental animals. Contributing to the ongoing drug discovery programs by conducting in vivo DMPK studies for NCEs with a good knowledge of in vivo animal models. Data generation, analysis, compilation, report preparation. Regular uploading of the data. Conduct statistically supported data (analysis usin...

Role & responsibilities Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training an...

Role & responsibilities Experience Minimum 3-5 years of experience in handling ADME assays and HPLC and LCMS/MS Skills and Capabilities Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis Should be well versed with internet-based literature search and capable of implem...

Job Title: Invitro BA Scientist Job Location: Bangalore, Hyderabad' About Syngene : Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit Mandatory expectation for all roles as per Syngene safety guidelines • Overall adherence to safe practices and procedures of oneself and the teams ...

Exciting Opportunity Alert - DMPK Roles at Syngene International! Are you passionate about drug discovery and eager to contribute to cutting-edge pharmaceutical research? Join us at Syngene International for the following roles: - ADME Scientist: MSc with 6-9 years or MPharma/Mtech with 3-6 years - Sr AS: MSc with 9-12 years, MPharm/Mtech with 6-9 years - Team Lead: Fresh PhD or MSc with 15-16 years, MPharma with 12-15 years - Sr Team Lead: PhD with 3-5 years of experience - Group Lead: PhD with 5-10 years - Senior Group Lead: PhD with 10+ years Fresh PhD candidates with relevant experience during academics or postdoc are also welcome. Key Skills Required: DMPK In vitro BA and In vitro ADME ...

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. : Medicinal chemistry; Research and development; Literature search; Scifinder / Reaxys; Design and synthesis; combiflash/Biotage; C-C coupling etc Qualifications MSC - Organic Chemistry.

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. Job description: Planning/performing and reporting of acute toxicology studies Assist in preparation of SOP"™s, Protocols and Reports Participate in GLP / AAALAC related activities Literature search Maintenance of animal house and relevant documents as per GLP and AAALAC norms. To Assist and work along with SD and TC in Plann...

Preferred candidate profile M. Pharm (Pharmacology) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 6-9 years or Ph.D. with 2-5 years' experience in PBPK & PK/PD modelling & Gastro plus; Simcyp software Role & responsibilities Experience in the development and application of pharmacometric models to support drug development and regulatory submissions Extensive experience with non-linear mixed effects modelling Proficient with software tools like PBPK models, Phoenix, R, PoPK, QSP modelling or similar platforms Strong background in pharmacokinetics/pharmacodynamics (PK/PD) modelling, First-in-human dose predictions. Collaborate with clinical pharmacology, biostatistics, and other inter...

Preferred candidate profile M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry / Analytical Chemistry) with 3 - 6 years experience in Bioanalytical DMPK & Invivo PK. Role & responsibilities Planning and execution of invivo preclinical pharmacokinetic studies, invivo tissue distribution & mass balance studies in rodents. Expert in method development of NCEs using LC-MS/MS system Well verse with extraction techniques of molecules from various matrices like plasma/urine/tissues Experienced in surgical skills for rodents PK, excretion studies Conduct Bioanalysis of samples from in-vivo pharmacokinetic, tissue distribution studies, PK-PD & TK studie...

Preferred Candidate Profile: M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry / Analytical Chemistry) with 5-8 years or Ph.D. with 2-5 years experience. Role & responsibilities Experience in designing, performing, and interpreting metabolite identification studies- Invitro and Invivo. Proficient in using LC-MS/MS, HRMS, and other analytical techniques for identification of metabolites and its soft spots. Ability to analyze complex data sets and structural interpretation for Phase-1, 2, and 3 metabolites. Strong understanding of drug metabolism principles and pathway. Experience with regulatory documentation and submissions Experience in DMPK ...

Role & responsibilities To perform in vitro ADME assays (solubility, metabolic and plasma stability, CYP inhibition, plasma protein binding studies etc.) Design, conduct and report data from in vitro metabolism studies using various cellular and subcellular systems, e.g., microsomes, hepatocytes, recombinant CYPs/UGTs and transfected cells. Perform assays using automated workstations. To design, program and implement study protocols in automated workstations. Ability to integrate metabolism and other supporting ADME data to predict druggability outcomes. To lead a group of 2-5 members and train juniors for the ongoing assays and technologies. Maintain labs & comply with SHE/regulatory guidel...

Hiring for Research Associate/ Sr. Research Associate for In- Vivo PK Studies -DMPK (Bangalore/Hyderabad Location) JOB DESCRIPTION Research Associate/ Senior Research Associate Department: Biology / DMPK Experience: 3-8 Years (In- Vivo PK studies) Key Responsibilities: Expert handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes like oral (p.o.), intravenous (i.v.), intraperitoneal (i.p.), subcutaneous (SC) etc. Cannulation of jugular vein, carotid artery, bile duct, portal vein and femoral vein in experimental rat model. Skilled in retro-orbital, Saphenous, Jugular bleeding, cardiac puncture, isolation of diffe...

Eurofins Advinus is a premier preclinical and early development CRO offering drug discovery, preclinical and development stage contract research services in the areas of discovery services, regulatory Toxicology (Safety Assessment), DMPK, Analytical R&D Services and API CDMO. Eurofins Advinus manufactures drug substances to support Toxicology and early clinical studies. With over 30 years of GLP compliance and certification, Eurofins Advinus serves diverse industries such as Biotech, Pharmaceutical, Biological, Agrochemical, Nutraceutical and Cosmetic. Eurofins Advinus is the only contract research organization (CRO) in India to have developed data in support of 90+ end-to-end IND enabling p...

Bioanalyst who will be responsible for high-quality discovery bioanalysis to support preclinical in vitro ADME and in vivo PK studies. LC-MS/MS based bioanalytical techniques to analyse biological samples in support of Drug Discovery projects. Required Candidate profile Around 5-8 years of experience in discovery bioanalysis to support in vitro ADME and pharmacokinetic studies.