Manager- Oligonucleotide Chemist/Peptide

Job Description

Job title: Manager ( Oligonucleotide Chemist /Peptide) Job Description: 1. Highly skilled and passionate oligonucleotide chemist to developing the next generation of RNA therapeutics. 2. The successful candidate will use state-of-the-art techniques to enhance RNA stability and improve cell delivery, as well as aid in the development of unique therapeutic platforms to discover new RNA molecules. 3. To lead the 2-3 chemists team along with responsibility of the person will systematically explore new and current chemical modifications to improve drug efficacy. He/she will be highly skilled in synthesising, analysing, and handling modified oligonucleotides and have the ability to adapt to a fast-paced research environment. Key Responsibilities: 1. Lead the development and chemical synthesis of modified oligonucleotides using automated solid phase synthesis (SPS) 2. Utilise a variety of purification and analytical techniques to evaluate the purity and structural integrity of newly synthesised ONs 3. Collaborate closely with closely with CFT team to understand the problems and solution. 4. Utilise expertise to generate libraries of therapeutic RNA and generate the data for AI algorithms Key Capabilities: 1. Excellent knowledge of solid phase ON synthesis,. 2. Phosphoramidite chemistry, and hands-on experience with automated ON synthesizers 3. Advanced and up-to-date knowledge of ON protecting groups and different deprotection strategies in SPS 4. Expertise in characterisation and purification of ONs and their conjugates by LCMS and HPLC 5. Strong analytical aptitude with an ability to work at the interface of chemistry and biology 6. Excellent communication and interpersonal skills 7. Ability to voice opinions and share ideas with the rest of the team 8. High professional integrity and commitment to excellence in execution 9. Passion for realizing the potential of fundamental scientific discoveries and commercialization Qualifications and work experience: 1. PhD or equivalent ( M.Sc organic chemistry) in ON/peptide/synthetic organic chemistry (postdoctoral or industrial experience in the SPS is preferred) 2. Strong understanding of nucleic acid modalities, modifications, and conjugation chemistry 3. Strong track record of scientific contributions, including peer reviewed publications or patent applications Scientist Position: Key Capabilities: 1. 3-5 years of work experience with M.Sc . organic chemistry 2. Good track record/excellent knowledge of solid phase ON synthesis/peptide synthesis 3. Excellent communication and interpersonal skills 4. Expertise in characterisation and purification of ONs and their conjugates by LCMS and HPLC 5. Planning in the daily reactions, maintain the LNB, safety 6. Good skills in purification 7. Knowledge in Identification and characterization of impurities 8. Experience in the preparation of PDR/MFR etc.. Qualifications and work experience: 1. M.Sc organic chemistry with 3-5 years of experience in Oligonucleotides/Peptides and complex molecules.