Characterization Specialist

#hiring. Know anyone who might be interested?

Veeda Lifesciences (Veeda Clinical Research)

Experience: with 3 to 6 yrs

Location: Bangalore

Interested candidates can share an updated CV to mahendra.t3705@veedalifesciences.com

Role & responsibilities:

Experiments

• Execution of planned experiments/studies using physico-chemical methods.
• Develop advanced LC-MS-based methodologies for the characterization of protein and peptide products.
• Design and implement integrated analytical strategies by combining chromatography and mass spectrometry techniques. These strategies aim to qualitatively and quantitatively assess product-related variants and impurities. This includes the development of innovative sample preparation methods, with a focus on LC-MS, CEX-MS, and SEC-MS, native MS, HDX as well as the characterization of innovator product batches sourced from various geographical regions to establish a comprehensive quality target profile.
• Lead the development of sophisticated analytical workflows, including multi-attribute methods for post-translational modifications (PTMs), sequence variant analysis, profiling of host cell proteins (HCPs), disulfide bond analysis and shuffling, cell culture metabolite analysis, and glycan profiling.

Data Generation

Sample preparation, data acquisition, data analysis/processing of HPLC/UPLC/LCMS/HRMS/CE based experiments/studies. Preferably on Thermo/Waters/Sciex platforms.

Interpretations

Scientific interpretations of processed data (manual/software-driven).

Reporting

Reporting of scientific data into suitable/approved report formats.

Data Integrity

Adherence to data integrity principles (ALOCA++) and quality compliance, as applicable.

Documentation

Preparation and up-keep of documents such as standard operating procedures, instrument/equipment related documents on qualification/validation, as applicable.

Instrumentation

Co-ordinate for maintaining the operational status of respective instrument/equipment with vendors/OEM.

Ad-hoc Studies

Execute ad-hoc studies/experiments/activities based on organizational needs/priorities.

Knowledge

Upskill with advancements in physico-chemical and/or structural characterization through literature surveys/webinars/conferences/symposiums.

Conferences

Participate in scientific meetings/interactions and present scientific data in form of posters/oral presentations/publications.