Invitro Research Scientist

AVE-Promagne Business Solutions

2 - 7 years

10 - 11 Lacs

Hyderabad

Posted:1 day ago| Platform:

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ADME Invitro Research Scientist Phoenix WinNonLin invitro

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Job Type

Full Time

Job Description

Your key responsibilities will include conducting In Vitro ADME studies. This involves reading and understanding various in vitro ADME protocols, as well as performing in vitro stability experiments for new chemical entities in liver microsomes, plasma, and other relevant matrices. You will also conduct specific in vitro ADME experiments such as logP, logD, pKa measurements, CYP induction and inhibition assays, permeability determinations, CYP phenotyping, and solubility determinations in various cell lines.
In addition to in vitro ADME studies, you will be involved in bioanalysis activities. This includes developing and validating LC-MS/MS and HPLC-UV/PDA methods, conducting bioanalytical QC, and handling bioanalytical method development for various matrices with a focus on in vitro samples. Experience in developing LC-MS/MS methods for biochemical and cell-based screening of NCEs is a plus. You will also be responsible for general LC-MS/MS and HPLC maintenance and troubleshooting tasks.Furthermore, as part of your role, you will be required to analyze data, generate reports, and share them with the line manager. This involves understanding the quality of bioanalytical data, conducting data analysis using software like Phoenix WinNonLin, calculating in vitro results/parameters using Excel spreadsheets, and generating reports in Excel, Word, and PowerPoint formats. You will also be responsible for generating reports in both GLP and non-GLP formats based on the requirements.

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AVE-Promagne Business Solutions

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Invitro Research Scientist