12 Adme Jobs

As the Group Lead of In-Vitro ADME at Syngene, you will lead a high-performing team of scientists in designing, executing, and interpreting complex in-vitro ADME and transporter studies that directly impact molecule progression decisions. Your core purpose will involve developing and evolving strategic in-vitro ADME and transporter capabilities aligned with current drug discovery needs. You will spearhead the design and interpretation of advanced cell- and non-cell-based ADME assays, ensuring robust and validated use of instrumentation such as Sirius T3 for pKa and logP measurement and LC-MS/MS for transporter studies. Your responsibilities will include leading evaluation and implementation of new assay formats for transporter kinetics, inhibition, and substrate specificity, driving automation initiatives, and assessing emerging technologies. Additionally, you will oversee quality, scalability, and compliance of transporter assays for regulatory and early discovery applications, while mentoring scientists and associates to foster a culture of ownership, accountability, and scientific curiosity within the team. Collaborating closely with cross-functional teams, you will serve as the scientific point-of-contact for DMPK-related deliverables, including transporter studies, in multi-disciplinary discovery programs. You will present strategic insights, transporter findings, and recommendations in internal and client-facing forums, contributing to reports and publications. Your role will also involve ensuring full adherence to Syngene's policies on data integrity, safety, ethics, and quality systems, and leading audit readiness of in-vitro ADME and transporter labs. To excel in this role, you should hold a Ph.D. in pharmaceutical sciences or biological science with 6-10 years of experience in drug discovery or an M Pharm. in pharmaceutical sciences with fifteen or more years of industrial experience in DMPK/ADME research. You should possess advanced knowledge of ADME & PK/PD, comprehensive understanding of in-vitro ADME assays, technical expertise in troubleshooting assays, and skills in data analysis tools like Microsoft Excel and GraphPad Prism. Additionally, you should demonstrate strong leadership, strategic decision-making, and effective communication skills. As a Syngene Leader, you will champion effective Environment, Occupational Health, Safety, and Sustainability practices within the organization, fostering a corporate culture that promotes EHSS mindset, quality, integrity, and compliance. By putting people at the heart of success and providing active leadership, you will set high standards of people management, career planning, and talent retention as key priorities. Syngene values excellence, integrity, and professionalism, and as a leader, you are expected to consistently demonstrate alignment with these core values. This role offers an opportunity to drive scientific innovation, lead a talented team, and contribute to impactful drug discovery projects in a dynamic and collaborative environment.,

You will be responsible for providing drug metabolism and pharmacokinetic support for discovery programs. Your main duties will include monitoring Pharmacokinetics studies, supporting bioanalysis, and offering pre-clinical ADME lead optimization support to small molecule Drug Discovery programs across various therapeutic areas. You will be working as a DMPK subject matter lead in multidisciplinary/cross-functional teams to understand the Chemical Structure ADME relationships and design appropriate strategies to enhance the Drug like Properties of the New Chemical Entities. To be successful in this role, you should have 2-5 years of experience in GLP with either an M.Sc. or Ph.D. degree. You should possess expertise in Bioanalysis using LC-MS/MS in both GLP and non-GLP environments. Additionally, you should be capable of leading projects as a DMPK representative, quantifying small molecules using LC-MS/MS, and conducting metabolite identification work on High-resolution mass spectrometry. Qualifications required for this position include an M. Pharm (Pharmacology / Pharmaceutical Analysis) or an M.Sc. (Biochemistry / Pharmaceutical Chemistry).,

Your key responsibilities will include conducting In Vitro ADME studies. This involves reading and understanding various in vitro ADME protocols, as well as performing in vitro stability experiments for new chemical entities in liver microsomes, plasma, and other relevant matrices. You will also conduct specific in vitro ADME experiments such as logP, logD, pKa measurements, CYP induction and inhibition assays, permeability determinations, CYP phenotyping, and solubility determinations in various cell lines. In addition to in vitro ADME studies, you will be involved in bioanalysis activities. This includes developing and validating LC-MS/MS and HPLC-UV/PDA methods, conducting bioanalytical QC, and handling bioanalytical method development for various matrices with a focus on in vitro samples. Experience in developing LC-MS/MS methods for biochemical and cell-based screening of NCEs is a plus. You will also be responsible for general LC-MS/MS and HPLC maintenance and troubleshooting tasks. Furthermore, as part of your role, you will be required to analyze data, generate reports, and share them with the line manager. This involves understanding the quality of bioanalytical data, conducting data analysis using software like Phoenix WinNonLin, calculating in vitro results/parameters using Excel spreadsheets, and generating reports in Excel, Word, and PowerPoint formats. You will also be responsible for generating reports in both GLP and non-GLP formats based on the requirements.

Role & responsibilities Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Preferred candidate profile A M Pharm. in pharmaceutical sciences or M SC in biological science with nine or more years of Industrial experience in DMPK/ADME research.

Role & responsibilities Experience Minimum 3-5 years of experience in handling ADME assays and HPLC and LCMS/MS Skills and Capabilities Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff General understanding of Drug metabolism and Pharmacokinetics Should be able to deliver scientific presentation in departmental journal club and write official Project reports Preferred candidate profile M. Pharm in Pharmaceutical sciences, Pharmaceutical Analysis who has interest and passion for LC/MS related bioanalysis.

Job Title: Invitro ADME Job Location: Bangalore/Hyderabad About Syngene Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit. Mandatory expectation for all roles as per Syngene safety guidelines Overall adherence to safe practices and procedures of oneself and the teams aligned. Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards. Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self. Compliance to Syngene s quality standards at all times. Hold self and their teams accountable for the achievement of safety goals Govern and Review safety metrics from time to time Job Purpose Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines. Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping Adhere to all safety rules and maintains safe workplace. Predominantly laboratory-based job Experience: 3- 10+years Education: Msc/Mpharm/Mtech/Phd/ Fresh phd with relevant exp during academics or any postdoc Key Responsibilities: Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Technical/functional Skills: Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism Demonstrated cross functional leadership capabilities Experience with automation is desirable Behavioral Skills: Demonstrate ability to be a team player. Commitment to deliver the study reports within the agreed timelines Adaptability to changes in the dynamic lab environment Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.

Job Title: Invitro Bioanalytical Scientist Job Location: Bangalore/Hyderabad About Syngene : Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit Mandatory expectation for all roles as per Syngene safety guidelines Overall adherence to safe practices and procedures of oneself and the teams aligned Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self Compliance to Syngene s quality standards at all times Hold self and their teams accountable for the achievement of safety goals Govern and Review safety metrics from time to time Core Purpose of the Role : To participate in sample processing for PK, ADME assays and handling of LCMS/MS. Ability to adapt to the dynamic team environment Processing of different matrices samples of PK studies Optimization of test compounds manually as well as automated on LCMS/MS Develop methods with the team lead Independently handling of HPLC for UV based samples analysis. Documenting the lab note books online and compound management Role Accountabilities Leadership Capabilities Syngene Values All employees will consistently demonstrate alignment with our core values Excellence Integrity Professionalism Accountabilities as a Syngene Leader (only for Leadership Hires) Champion effective Environment, Occupational Health, Safety and Sustainability (EHSS) practices for the company and oversee compliance with those practices within Biologics business. Play an active leadership role in monitoring and verifying safety performance through Gemba walks and other safety-led activities. Foster a corporate culture that promotes an environment, occupational health, safety, and sustainability (EHSS) mindset as well as the highest standards of quality, integrity, and compliance. Put people at the heart of our success by providing clear, active leadership defined by the Syngene leadership framework setting high standards of people management, career planning and talent retention as a priority. Specific requirements for this role 1. Experience 2. Demonstrated Capability 3. Education Experience Minimum 3-5 years of experience in handling ADME assays and HPLC and LCMS/MS Skills and Capabilities Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff General understanding of Drug metabolism and Pharmacokinetics Should be able to deliver scientific presentation in departmental journal club and write official Project reports Education M. Pharm in Pharmaceutical sciences, Pharmaceutical Analysis who has interest and passion for LC/MS related bioanalysis.

Job Title: ADME Scientist Job Location: Bangalore/Hyderabad Department: Discovery Biology About Syngene Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation. Job Purpose Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines. Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping Adhere to all safety rules and maintains safe workplace. Predominantly laboratory-based job Key Responsibilities: Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Educational Qualification: A M Pharm. in any pharmaceutical science or M Sc. in biological science. Technical/functional Skills: Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism Demonstrated cross functional leadership capabilities Experience with automation is desirable Experience: A M Pharm. in pharmaceutical sciences or M SC in biological science with nine or more years of Industrial experience in DMPK/ADME research. Behavioral Skills: Demonstrate ability to be a team player. Commitment to deliver the study reports within the agreed timelines Adaptability to changes in the dynamic lab environment Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.

Exciting Opportunity Alert - DMPK Roles at Syngene International! Are you passionate about drug discovery and eager to contribute to cutting-edge pharmaceutical research? Join us at Syngene International for the following roles: - ADME Scientist: MSc with 6-9 years or MPharma/Mtech with 3-6 years - Sr AS: MSc with 9-12 years, MPharm/Mtech with 6-9 years - Team Lead: Fresh PhD or MSc with 15-16 years, MPharma with 12-15 years - Sr Team Lead: PhD with 3-5 years of experience - Group Lead: PhD with 5-10 years - Senior Group Lead: PhD with 10+ years Fresh PhD candidates with relevant experience during academics or postdoc are also welcome. Key Skills Required: DMPK In vitro BA and In vitro ADME Kindly note that there are no current requirements for "In vivo BA" and "In vivo PK" positions. Please share your resumes at: Sulake.Divyasree@Syngeneintl.com Core Purpose of the Role: Lead the team of bioanalysts responsible for delivering high quality data for requested ADME studies withing agreed timelines Expertise in automated discovery bioanalysis workflow practices for both small and large molecules and new drug modalities like Protacs, ADCs, Oligonucleotides etc. Updated with the latest innovations in high throughput bioanalysis, both at instruments levels and data management Sound understanding of DMPK principles and have mandatory experience in handling global clients Comprehend outcome of various in-vitro/in-vivo assays and contribute to integrated drug discovery Projects as DMPK representative

Role & responsibilities To perform in vitro ADME assays (solubility, metabolic and plasma stability, CYP inhibition, plasma protein binding studies etc.) Design, conduct and report data from in vitro metabolism studies using various cellular and subcellular systems, e.g., microsomes, hepatocytes, recombinant CYPs/UGTs and transfected cells. Perform assays using automated workstations. To design, program and implement study protocols in automated workstations. Ability to integrate metabolism and other supporting ADME data to predict druggability outcomes. To lead a group of 2-5 members and train juniors for the ongoing assays and technologies. Maintain labs & comply with SHE/regulatory guidelines. Preferred candidate profile Masters with 10+ years of PhD with 2+ years industry experience in Invitro ADME assays.

You get to collaborate on Medicinal Chemistry of Lead Generation and Lead Optimization of Pipeline Projects. Understand Structure Activity Relationships and Structure Property Relationships of various projects. Collaborate with Medicinal Chemistry, Pharmacology, Analytical, ADME, Tox, IP, Site and Global Leadership. Develop appropriate flow schemes with relevant in vitro, in vivo, ADME/PK and tox studies. Appropriate allocation of resources for maximum cost effectiveness. Work effectively with Project ManagementMake presentations of your projects at various Enveda forums. You work with the site safety head and emphasize the importance of safe practices in the chemistry laboratories Who will thrive in this role Doctor of Philosophy in Synthetic Organic Chemistry15-20 years of post-PhD experience in Medicinal Chemistry Proven track record of delivery of leads and clinical candidates to the pharmaceutical industry. Management and mentoring of synthetic chemists. Good understanding of intellectual property of medicinally valuable compounds with respect to composition of matter, method of use and chemical processes. Strong understanding of safety practices in organic synthesis laboratories. If you don't meet all of the requirements listed here, we still encourage you to apply. No job description is perfect, and we might find an even more suitable opportunity that matches your experience.

Bioanalyst who will be responsible for high-quality discovery bioanalysis to support preclinical in vitro ADME and in vivo PK studies. LC-MS/MS based bioanalytical techniques to analyse biological samples in support of Drug Discovery projects. Required Candidate profile Around 5-8 years of experience in discovery bioanalysis to support in vitro ADME and pharmacokinetic studies.