RNA Delivery Formulation Discovery and Characterization Scientist

We are looking for both junior and senior scientists to join our team and contribute to the development of our novel mRNA-based vaccines and therapeutics. The ideal candidates will have experience in nucleic acid delivery systems, particularly focusing on lipid or polymer-based formulations, and will work on advancing our platform for efficient, long-term mRNA stability and delivery. The role will involve formulation discovery, microfluidics, particle size analysis, and nucleic acid quantification in a collaborative, fast-paced environment.

Key Responsibilities:

• Design, develop, and optimize lipid nanoparticle (LNP) or polymeric formulations for nucleic acid delivery (RNA or DNA), with a focus on mRNA.
• Conduct microfluidics experiments to synthesize, encapsulate, and characterize lipid or polymeric nanoparticles.
• Perform formulation characterization, including particle size and zeta potential measurements, pKa determination, and viscosity assessments.
• Quantify nucleic acids using RiboGreen, NanoDrop spectrophotometry, and other relevant techniques.
• Utilize gel electrophoresis for nucleic acid and protein analysis (including Western blotting).
• Implement and refine nanoparticle purification techniques, such as ultrafiltration and tangential flow filtration (TFF).
• Conduct cell-culture experiments, including transfection of immortalized cell lines with nucleic acids or nucleic acid formulations.
• Set up and conduct high-throughput in vitro screening assays for evaluating formulation effectiveness.
• Support the setup and automation of laboratory protocols, including lab automation equipment setup and programming.
• Participate in animal studies to evaluate drug or vaccine delivery formulations.
• Collaborate with cross-functional teams to troubleshoot and solve technical challenges in formulation and characterization.
• Contribute to the continuous improvement of experimental techniques and methodologies.

Qualifications:

• MSc or PhD in Life Sciences, Chemistry, Biophysics, Chemical Engineering, or a related discipline, with substantial experience in nucleic acid delivery or adjacent delivery modalities.
• Proven track record of successful project execution in nucleic acid delivery, formulation, or related fields.
• Solid experience in lipid or polymer-based drug delivery, ideally for mRNA or nucleic acids.
• Familiarity with microfluidics techniques for nanoparticle synthesis and characterization.
• Experience with nanoparticle characterization techniques, including size analysis, zeta potential, viscosity, and pKa determination.
• Expertise in nucleic acid quantification techniques such as RiboGreen assays, NanoDrop spectrophotometry, and gel electrophoresis.
• Experience with cell-based assays (e.g., reporter assays, ELISA) and transfection of nucleic acids.
• Experience with high-throughput screening methods and assay automation is desirable.
• Strong analytical and problem-solving skills with the ability to independently interpret experimental data and troubleshoot technical issues.
• Excellent communication skills, both written and verbal, with the ability to present scientific findings clearly and effectively.
• A collaborative mindset and ability to work in interdisciplinary teams.
• Self-motivated with a strong desire to rapidly learn and master new experimental techniques.

Desired Experience (Not Required for All Candidates):

• Experience with formulation purification techniques, such as ultrafiltration and TFF.
• Experience in animal studies related to nucleic acid delivery.
• Familiarity with lab automation or the programming of lab automation systems.

What We Offer:

• Competitive compensation.
• Comprehensive health insurance with coverage options for immediate family (including pre-existing conditions).
• A collaborative, multidisciplinary work environment focused on tackling innovative challenges in mRNA delivery and therapeutics.
• Opportunities for professional growth and contribution to groundbreaking biotechnology advancements.

PopVax is committed to creating an inclusive, diverse environment and is proud to be an equal-opportunity employer. We encourage individuals from all backgrounds to apply.