RNA Delivery Formulation Discovery and Characterization Scientist University Of Cambridge

5.0 - 9.0 years

5 - 9 Lacs

Hyderabad, Telangana, India

On-site

We are looking for both junior and senior scientists to join our team and contribute to the development of our novel mRNA-based vaccines and therapeutics. The ideal candidates will have experience in nucleic acid delivery systems, particularly focusing on lipid or polymer-based formulations, and will work on advancing our platform for efficient, long-term mRNA stability and delivery. The role will involve formulation discovery, microfluidics, particle size analysis, and nucleic acid quantification in a collaborative, fast-paced environment. Key Responsibilities: Design, develop, and optimize lipid nanoparticle (LNP) or polymeric formulations for nucleic acid delivery (RNA or DNA), with a focus on mRNA. Conduct microfluidics experiments to synthesize, encapsulate, and characterize lipid or polymeric nanoparticles. Perform formulation characterization, including particle size and zeta potential measurements, pKa determination, and viscosity assessments. Quantify nucleic acids using RiboGreen, NanoDrop spectrophotometry, and other relevant techniques. Utilize gel electrophoresis for nucleic acid and protein analysis (including Western blotting). Implement and refine nanoparticle purification techniques, such as ultrafiltration and tangential flow filtration (TFF). Conduct cell-culture experiments, including transfection of immortalized cell lines with nucleic acids or nucleic acid formulations. Set up and conduct high-throughput in vitro screening assays for evaluating formulation effectiveness. Support the setup and automation of laboratory protocols, including lab automation equipment setup and programming. Participate in animal studies to evaluate drug or vaccine delivery formulations. Collaborate with cross-functional teams to troubleshoot and solve technical challenges in formulation and characterization. Contribute to the continuous improvement of experimental techniques and methodologies. Qualifications: MSc or PhD in Life Sciences, Chemistry, Biophysics, Chemical Engineering, or a related discipline, with substantial experience in nucleic acid delivery or adjacent delivery modalities. Proven track record of successful project execution in nucleic acid delivery, formulation, or related fields. Solid experience in lipid or polymer-based drug delivery, ideally for mRNA or nucleic acids. Familiarity with microfluidics techniques for nanoparticle synthesis and characterization. Experience with nanoparticle characterization techniques, including size analysis, zeta potential, viscosity, and pKa determination. Expertise in nucleic acid quantification techniques such as RiboGreen assays, NanoDrop spectrophotometry, and gel electrophoresis. Experience with cell-based assays (e.g., reporter assays, ELISA) and transfection of nucleic acids. Experience with high-throughput screening methods and assay automation is desirable. Strong analytical and problem-solving skills with the ability to independently interpret experimental data and troubleshoot technical issues. Excellent communication skills, both written and verbal, with the ability to present scientific findings clearly and effectively. A collaborative mindset and ability to work in interdisciplinary teams. Self-motivated with a strong desire to rapidly learn and master new experimental techniques. Desired Experience (Not Required for All Candidates): Experience with formulation purification techniques, such as ultrafiltration and TFF. Experience in animal studies related to nucleic acid delivery. Familiarity with lab automation or the programming of lab automation systems. What We Offer: Competitive compensation. Comprehensive health insurance with coverage options for immediate family (including pre-existing conditions). A collaborative, multidisciplinary work environment focused on tackling innovative challenges in mRNA delivery and therapeutics. Opportunities for professional growth and contribution to groundbreaking biotechnology advancements. PopVax is committed to creating an inclusive, diverse environment and is proud to be an equal-opportunity employer. We encourage individuals from all backgrounds to apply.

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Research Assistant ( Jewellery) H R D Diamond Institute

0.0 years

1 - 5 Lacs

Navi Mumbai, Jaipur, Mumbai (All Areas)

Work from Office

Key Responsibilities: Working on machines in Labs for Diamond & Jewellery Experience: Any Fresher or Min 1 years of experience of working on machines in Labs for Diamond & Jewellery Precise in working and handling Diamonds & Jewellery Required Skills: Flexible in working hours Smart and presentable Good communication skills Can talk, read & communicate in English Open for Multitasking work culture Education & Certifications: Min B.Sc - Physics or Chemistry or Graduate Work Environment : Able to travel to multiple locations as and when required May occasionally be required to work overtime to meet deadlines.

Posted 1 month ago

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