Production Supervisor

Granulation & Compression Executive:

Work Location:

Employment Type

)

About the Role

granulation and compression operations

Key Responsibilities

Granulation

• Execute wet/dry granulation as per BMR/BPR and SOPs, ensuring compliance with cGMP.
• Operate and monitor equipment:

  RMG/High Shear Mixer, FBD, Fluid Bed Processor, Multi-mill, Sifter, Blenders (Bin/Octagonal)

  .
• Perform pre-use checks, line clearance, and in-process controls (LOD, granule size distribution, blending uniformity).
• Coordinate with QA for

  IPQA checks

  , sampling, and batch release activities.
• Ensure proper cleaning, CIP/SIP where applicable, and status labelling (Cleaned/In-Use/Under Maintenance).

Compression

• Set up and run

  tablet presses

  (e.g.,

  Fette, Korsch, Cadmach, Sejong

  ), feeders, and dedusters; manage

  metal detector

  checks.
• Perform

  in-process testing

  : tablet weight, thickness, hardness, friability, DT, and appearance per control strategy.
• Manage tooling (B/D, punches & dies) inspection, preventive maintenance coordination, and changeover.
• Troubleshoot compression issues (capping, lamination, picking, sticking, weight variation) via parameter optimization.
• Coordinate with

  coating

  /packaging teams for downstream readiness and timely batch progression.

Compliance & Documentation

• Maintain

  cGMP, GLP, Data Integrity

  (ALCOA+) in all records.
• Complete and reconcile

  BMR/BPR

  , logbooks, e-records; support

  line clearance

  and deviation handling.
• Participate in

  investigations (deviations/OOS/OOT)

  ,

  CAPA

  , and change controls.
• Support

  qualification/validation

  : URS, IQ/OQ/PQ, and process validation batches.
• Ensure adherence to

  SOPs, EHS guidelines

  , and statutory & regulatory requirements.

Operational Excellence

• Drive

  5S

  , Kaizen, and yield/cycle-time improvements; reduce compression rejections and downtime.
• Plan and execute batches to meet production targets; track

  OEE

  and key KPIs.
• Coordinate with

  Planning, QA, QC, Engineering

  for smooth execution.
• Train operators on GMP, equipment handling, and safety; foster a culture of continuous improvement.

Qualifications

• B.Pharm / M.Pharm

  or equivalent.

• 3 to 8 years

  experience in

  granulation and compression

  within a regulated pharma environment (USFDA/MHRA/WHO/EU GMP Only). No Domestic.

Technical Skills

• Strong knowledge of

  granulation theory

  , compression mechanics, and tablet defects & remedies.
• Hands-on with

  RMG, FBD, blenders, tablet presses, deduster, metal detector

  .
• Familiarity with

  process validation, cleaning validation

  , and

  IPQA

  requirements.
• Proficiency in

  GMP documentation

  ,

  SOPs

  , and

  data integrity

  practices.
• Basic understanding of

  QMS

  , root-cause analysis tools (

  Fishbone, 5-Why

  ), and

  CAPA

  .

Behavioral Competencies

• Ownership & attention to detail; strong troubleshooting mindset.
• Effective communicator and team collaborator across QA/QC/Engineering.
• Ability to work in

  shifts

  and manage multiple batches under tight timelines.

Tools & Systems

• Familiarity with

  MES/e-BMR

  , ERP (SAP/Oracle), and basic MS Office is must.

Key Performance Indicators (KPIs)

• Batch right-first-time (RFT), yield, rejection %,

  OEE

  , deviations/CAPA closure time.
• Compliance (documentation accuracy, audit observations), productivity & adherence to plan.

How to Apply

[Khaleel.md@granulesindia.com]

Contact: