Principal Scientist | T-cell immunology

We are seeking an exceptional, experienced senior immunologist with specific expertise in T-cell biology, hands-on experience with T-cell isolation, stimulation and enrichment protocols, in-depth knowledge of TCR discovery, and assays related to measuring T-cell potency and cytokine release.

RESPONSIBILITIES

• Maintenance and handling of primary immune cells from various sources

• Contribute to the design of TCRs and TCR-mimics

• Lead discovery campaigns to generate TCRs via stimulation assays (medium throughput or high throughput fashion)

• Plan and execute in vitro and in vivo experiments to comprehensively characterise the potency of both designed and discovered TCRs.

• Lead communication and drive collaboration between the immunology and the antigen design, mRNA, and formulation teams

• Develop study outlines, detailed timelines and oversee the logistics for execution of parallel and staggered experiments

• Ensure effective and thorough documentation, analysis, and interpretation of the experimental data generated by the immunology team

• Mentor juniors and lead a team to take independent decisions for experimental designs

QUALIFICATIONS

• PhD and 8+ years or Masters and 10+ years of experience in immunology, biochemistry, life sciences, or a related discipline, with a minimum of 5 years of experience in TCR discovery and development in academia or industry

• Experience in performing and in-depth understanding of routine immunology techniques such as ELISA, ELISPOT, multiplex assays, and multi-colour flow cytometry, including intracellular cytokine staining

• In-depth understanding of T-cell biology, and downstream therapeutics, including CAR-T and T-cell engagers

• Familiarity with data analysis software such as FlowJo and Prism

• Strong written and oral communication skills

• A proven track record of research publications and, ideally, presentations at research conferences

• Proven leadership and mentorship experience in pre-clinical research and development

We offer very competitive compensation, comprehensive health insurance covering immediate family (including pre-existing conditions), and, most importantly, a collaborative work environment focused on solving the cutting-edge multidisciplinary challenges of our novel mRNA platform.