Lead - Medicinal Chemist

Role & responsibilities Lead medicinal chemistry strategies for the design, synthesis, and optimization of novel drug candidates. Execute SAR (Structure-Activity Relationship) strategies to improve potency, selectivity, and overall drug-like properties. Drive hit-to-lead and lead optimization efforts across multiple discovery programs. Incorporate AI-driven drug design and computational modeling into medicinal chemistry workflow. Manage external collaborations with CROs' and academic partners to scale compound synthesis and profiling. Partner closely with biology, pharmacology, DMPK, and analytical chemistry to integrate data and advance candidates efficiently Analyse experimental results, generate hypotheses, and make data-driven decisions to guide programs. Build and mentor a team of medicinal chemists, fostering scientific innovation and Professional growth. Remain hands-on in chemistry when needed, applying creativity and rigour to overcome key design challenges. Preferred candidate profile PhD in Organic or Medicinal Chemistry (or a related discipline) with 10+ years of industry experience in drug discovery. Demonstrated leadership in advancing small molecules or peptides into the clinic. Deep expertise in synthetic chemistry, drug design, and SAR optimization. Exposure to AI-based drug discovery, computational chemistry, or fragment-based design. Solid understanding of DMPK, pharmacology, and safety assessment in early development Familiarity with patent strategy and regulatory considerations for small-molecule therapeutics Proven ability to manage cross-functional projects and external partnerships Excellent communication, leadership, and decision-making skills