Research And Development Chemist

Job Purpose:

To carry out literature surveys, design synthetic routes, and perform multi-step organic synthesis for development and optimization of API molecules in line with regulatory and project timelines.

Location

Department

Reporting to

Experience

Education

Key Responsibilities

• Route Design and Synthesis

  :
• Conduct literature and patent searches (e.g., using SciFinder, Reaxys).
  
• Propose and develop synthetic routes for new and existing APIs.
  
• Synthesize intermediates and APIs on lab scale.
  

• Process Development

  :
• Optimize reactions for yield, purity, and scalability.
  
• Participate in scale-up activities from lab to kilo lab and pilot plant.
  
• Develop cost-effective and environmentally friendly processes.
  

• Analytical Support

  :
• Work with Analytical R&D to characterize synthesized compounds (e.g., NMR, HPLC, GC, IR, MS).
  
• Prepare samples for stability and impurity profiling.
  

• Documentation

  :
• Maintain accurate and detailed lab notebooks.
  
• Draft technical documents: process development reports, technology transfer dossiers, etc.
  
• Ensure compliance with regulatory guidelines (ICH, GMP, etc.).
  

• Collaboration

  :
• Interact with cross-functional teams Analytical, Regulatory Affairs, QA/QC, and Manufacturing.
  
• Support technology transfer to manufacturing locations.
  

Key Skills and Competencies

• Strong theoretical and practical knowledge in

  organic synthesis

  and reaction mechanisms.
• Familiarity with

  GMP practices

  , regulatory norms (ICH Q11, Q7).
• Experience in

  reaction optimization

  ,

  purification techniques

  , and

  problem solving

  .
• Proficiency in tools like

  SciFinder, Reaxys

  , and analytical instruments (HPLC, NMR, GC).
• Good communication skills and teamwork orientation.
  
• Ability to handle multiple projects and meet tight deadlines.