Manager / Sr. Manager - Downstream Processing, R&D

Best fit profile

• Knowledge in handling and troubleshooting purification methods at small scale and pilot scale
• Various Chromatography techniques like Ion exchange, Affinity, HIC etc.
• Ultrafiltration TFF (Hollow Fiber/Cassettes).
• Should be well versed with FPLC, AKTA- Process, AKTA- Pilot.

Responsibilities

• Purification method development, optimization, & execution for bacterial & viral vaccines.
• Experience in Cell lysis, different chromatography platform, TFF system, Filtration unit and other unit operations used in protein purification.
• Purification method optimization and development for protein expressing in E.coli and mammalian cell culture.
• Execution of In House Calibration of AKTA System, spectrophotometer, Auto pipettes, Weighing balance and supervision of In House Calibration of pH /conductivity meter.
• Execution of scale up & scale down experiment for purification of Vaccines and biologics to obtain high yield & quality product.
• Downstream Process development, optimization & scale up of different vaccine bulk (Dengue Vaccine, Hepatitis A Vaccine and E.coli, BPBC /CEPI Vaccine).
• Co-ordination with technology transfer of production process and prioritization of tasks and completion of those in a timely manner.
• Any other responsibilities as assigned by R&D Head.
• Literature, research paper review and its implementation of new ideas.
• Preparation of process development report, process consistency report as per timelines.
• Preparation of SOPs, BPRs, protocol report and other documents required for R &D related activities
• IQ, OQ and PQ of new equipment's to be installed in downstream processing area.

Qualifications

• PhD/M.SC in Biotechnology.
• Having experience in Down Stream process (Protein Purification).
• Preferably from R&D setup.

Experience

Post PhD - 8+ Years of experience

Post master's - 16+ Years of experience