Lead Preclinical Science ( Neuroscience and Translational Research)

As a critical member of the team, your primary responsibility will be to drive the design, execution, and interpretation of preclinical studies to support the discovery and development of novel therapeutics for neurological disorders. Your deep expertise in neuroscience, pharmacology, and translational science will play a key role in advancing drug candidates, including biologics and gene therapies, from early discovery through IND-enabling studies. **Key Responsibilities:** - Lead preclinical strategy and execution for neuroscience drug discovery programs. - Design and oversee in vivo and in vitro studies to evaluate pharmacodynamics, efficacy, and safety. - Guide target validation, biomarker development, and mechanism-of-action studies. - Serve as the preclinical lead on cross-functional project teams. - Collaborate with various teams to ensure seamless transition from discovery to development. - Mentor and supervise a team of scientists and research associates. - Identify and manage CROs and academic partnerships to support preclinical research. - Contribute to the preparation of regulatory documents including INDs, IBs, and briefing packages. - Support IND-enabling studies and contribute to regulatory submissions. **Qualifications:** - Ph.D. in Neuroscience, Pharmacology, or related discipline; postdoctoral experience preferred. - 8+ years of relevant experience in preclinical drug discovery. - Proven track record in leading neuroscience programs to preclinical candidate nomination. - Expertise in neurobiology, in vivo pharmacology, and translational models of CNS disorders. - Strong leadership, communication, and project management skills. - Experience with IND-enabling studies and regulatory documentation. - Publication record in high-impact neuroscience or pharmacology journals. In addition to the above qualifications, you should have hands-on experience with various neurological animal models, in vivo neuroscience expertise, behavioral phenotyping, histological and molecular analysis, electrophysiology and imaging, cell-based assays, drug testing, and gene therapy product testing. Your proficiency in data analysis, statistical operations, and knowledge in areas such as neuroimmunology, synaptic biology, and neurodevelopmental disorders will be invaluable in this role. Please note that this position operates in an office setting, with limited remote work availability. Your dedication and expertise will contribute significantly to the advancement of preclinical research in the field of neurological disorders.,