3 Safety Assessment Jobs

As a Medicinal Chemistry leader at Alembic, you will be at the forefront of driving the next wave of therapeutic innovation. Your role will involve shaping the future of drug discovery from India and bridging into the U.S. biotech ecosystem. Based in Hyderabad Genome Valley, you will work full-time and report to the Head of Drug Discovery at Alembic. You will be tasked with spearheading small-molecule and peptide drug discovery efforts, shaping and executing innovative strategies that drive programs from target identification to nominating clinical candidates. Alembic is seeking a visionary and accomplished leader with a track record of advancing compounds from early discovery to IND-enabling studies. The ideal candidate will possess deep expertise in medicinal chemistry, hands-on problem-solving skills, and preferably experience in computational chemistry or AI-enabled design. Your key responsibilities will include leading medicinal chemistry strategies for designing, synthesizing, and optimizing novel drug candidates. You will execute SAR strategies to enhance potency, selectivity, and overall drug-like properties, driving hit-to-lead and lead optimization efforts across multiple discovery programs. Additionally, you will incorporate AI-driven drug design and computational modeling into the medicinal chemistry workflow and manage external collaborations with CROs and academic partners. Furthermore, you will partner closely with various teams such as biology, pharmacology, DMPK, and analytical chemistry to integrate data and advance candidates efficiently. Your role will also involve analyzing experimental results, generating hypotheses, and making data-driven decisions to guide programs. Building and mentoring a team of medicinal chemists to foster scientific innovation and professional growth will also be a part of your responsibilities. To qualify for this role, you should hold a PhD in Organic or Medicinal Chemistry (or a related discipline) with over 10 years of industry experience in drug discovery. Demonstrated leadership in advancing small molecules or peptides into the clinic, deep expertise in synthetic chemistry, drug design, and SAR optimization are essential. Exposure to AI-based drug discovery, computational chemistry, or fragment-based design will be advantageous. Strong communication, leadership, and decision-making skills are also required. By joining Alembic, you will lead cutting-edge medicinal chemistry initiatives, collaborate with world-class scientists in an innovation-driven culture, play a central role in shaping Alembic's emerging therapeutic pipeline, and contribute to an organization committed to scientific rigor, global impact, and patient health. Alembic embraces diversity and is dedicated to building an inclusive team.,

Job Summary: This dual customer/product focused position serves as the senior technical liaison between OEMs and represents our customers during new product development programs. Applying Cummins products to customer vehicles requires the development of technical specifications, implementing new design configurations, and delivering high performance, low-cost equipment and system solutions integrated with customers products in a variety of applications. Integrating high quality and optimized customer solutions requires the interaction with sales and marketing teams. Key Responsibilities: Obtains input and negotiates with Subject Matter Experts and Value Package Introduction (VPI) Teams and delivers product data and installation requirements to Application Engineers and OEMs Makes decisions in the areas of product selection, design, and integration that impact OEM machine performance, optimization and quality Applies and improves processes such as Installation Quality Assurance, OEM integration and product selection and tools such as Advisor, Cummins OnLine Specifications (COLS) and Global Customer Engineering (GCE) required to support the processes and enable high quality decision making Develops strong working relationships with customer technical counterparts to serve as their primary liaison to deliver specialized product technical information, manage product specifications, communicate product change information, conduct complex installation issue resolutions and facilitate customer requests Applies technical expertise in the areas of product, application and market knowledge to support OEM product selection and equipment design Leads the translation of customer needs and "voice of the customer" into functional product requirements to provide input on program-related decisions Serves as customer/market advocate inside Cummins during participation in new product development programs, design reviews and product change request processes Ensures products are applied and installed correctly to meet customer system requirements and environments Assures installation quality by validating prototype machine performance and ensuring installations meet Cummins requirements Utilizes Analysis Led Design (ALD) and Six Sigma tools to optimize product and system performance Proposes innovative customer-focused initiatives and projects Assists with the transfer of knowledge through coaching and mentoring less experienced engineers Provides independent leadership of smaller business impact projects or ownership of complex components, products, systems or services with greater elements of ambiguity over the senior or lead engineer level and with full accountability to the project team Delivers independent execution of established and emerging work processes and systems, while still developing technology or product knowledge Leads the development and improvement of work processes and systems across a functional discipline area within a business unit site Coordinates and directs work amongst technicians and temporary student employees, assists in the transfer of knowledge to lesser experienced engineers through either indirect (scope of influence) or direct management of a small, local group of engineers Provides support and guidance to influence technical direction within a project team and continues to develop proficiency in the competency areas critical to success in the role Operates as a recognized specialist in a discipline or product area within the immediate team Overall 10+ years of industry experience, with: 5+ years of experience in getting design documents approved by various Indian Railway Factory/RDSO for rolling stock applications 2+ years of experience in conducting integrated system testing for Vande Bharat/EMU/MEMU Experience in preparing vehicle requirements, system requirements, and interface control documents for Train Control and Management Systems (TCMS) Strong expertise in creating technical documentation, including SOW documents, Software Design documents, Test Plans, and Project Plans Demonstrated experience in conducting and leading technical meetings across mechanical, electrical, and software design teams Knowledge and experience in developing safety assessment plans and preparing documentation for safety audits and certifications Experience in leading and participating in integrated system testing for rail transportation projects Proficiency in MS Office tools External Qualifications and Competencies Competencies: Machine Integration and Optimization - Combines various parts or sub-systems into a whole to achieve the output most desired by the customer; applies Cummins' installation requirements using our standard tools, processes and identified best practices to ensure optimization of performance, reliability, cost and quality; analyzes technical issues using proven problem-solving and troubleshooting techniques for rapid resolution. Product Application Support - Ensures new product information is available by developing and managing accurate and complete technical content in a timely manner to support our customers and the business; provides new options through management of technical systems to support sales to all of our markets; defines installation requirements and develops innovative tools with in-depth, cross-system knowledge and industry experience for successful design and integration. Product Function Modeling, Simulation and Analysis - Impacts product design decisions through the utilization and/or interpretation of computational tools and methods that predict the capability of a product's function relative to its system, sub-system and/or component level requirements. Product Installation Quality - Identifies and applies ways to improve machine integration to minimize rework and deliver the best product; applies standard Cummins processes based on the experience and knowledge of product installation experts; ensures that products are installed correctly and meet requirements through an installation review process. Product Problem Solving - Solves product problems using a process that protects the customer; determines the assignable cause; implements robust, data-based solutions; and identifies the systemic root causes and recommended actions to prevent problem reoccurrence. Product Selection - Guides customers to the best product offerings for their markets and applications; offers best-fit solutions to customers by optimizing product specifications to make Cummins' offerings easy to install into new applications; represents features and benefits of products in terms that customers understand; ensures Cummins' products aren't misapplied through using Cummins' technical information systems, local and application requirements. Technical Customer Management - Represents Cummins to our customers by being the interface for all technical aspects; provides engineering data, documentation and training to customers to support the design and integration of equipment; ensures that the customer's business is not interrupted by managing Cummins' product changes through the use of our change processes and regular communications with Product Development and the customer. Builds networks - Effectively building formal and informal relationship networks inside and outside the organization. Communicates effectively - Developing and delivering multi-mode communications that convey a clear understanding of the unique needs of different audiences. Customer focus - Building strong customer relationships and delivering customer-centric solutions. Decision quality - Making good and timely decisions that keep the organization moving forward. Drives results - Consistently achieving results, even under tough circumstances. Manages complexity - Making sense of complex, high quantity, and sometimes contradictory information to effectively solve problems. Resourcefulness - Securing and deploying resources effectively and efficiently. Values differences - Recognizing the value that different perspectives and cultures bring to an organization. Education, Licenses, Certifications: College, university, or equivalent Bachelor's degree in Engineering or appropriate STEM field is required. Post-graduate (Master's) degree relevant to this discipline area may be required for select roles. This position may require licensing for compliance with export controls or sanctions regulations. Experience: Prior Senior or Lead Engineer equivalent work experience in a relevant discipline area is required with a demonstrated track record of technical problem solving and quality decision making. Knowledge of MS Office tools is preferred

look to you for: Planning and executing Independent Safety Assessment activities for assigned projects Applying and contributing to the continuous improvement of safety assessment processes and tools Delivering clear and comprehensive safety assessment reports Presenting results and managing communications with project teams and external entities Supporting the Independent Safety Assessment director or Safety Assessment lead in capturing assessment requests Contributing to the success of internal/external audits on process compliance Master Degree in Engineering or a similar technical field Experience in the railway safety domain or extensive experience in the railway domain with a focus on safety Knowledge of Alstom Ethics & Compliance policy and EHS policy Experience in conducting audits A certification in World Class Engineering (WCE) Expert in Safety is advantageous Fluency in English with excellent communication skills Resilience and negotiation skills