Job
Description
Role Overview: As a critical member of the team, you will be responsible for driving the design, execution, and interpretation of preclinical studies to support the discovery and development of novel therapeutics for neurological disorders. Your expertise in neuroscience, pharmacology, and translational science will be instrumental in advancing drug candidates, including biologics and gene therapies, from early discovery through IND-enabling studies. Key Responsibilities: - Lead preclinical strategy and execution for neuroscience drug discovery programs. - Design and oversee in vivo and in vitro studies to evaluate pharmacodynamics, efficacy, and safety. - Guide target validation, biomarker development, and mechanism-of-action studies. - Serve as the preclinical lead on cross-functional project teams. - Collaborate with medicinal chemistry, DMPK, toxicology, and clinical teams for seamless transition from discovery to development. - Mentor and supervise a team of scientists and research associates. - Identify and manage CROs and academic partnerships for preclinical research support. - Contribute to the preparation of regulatory documents including INDs, IBs, and briefing packages. - Support IND-enabling studies and contribute to regulatory submissions. - Translate preclinical findings into clinical hypotheses and biomarker strategies. Qualifications: - Ph.D. in Neuroscience, Pharmacology, or related discipline; postdoctoral experience preferred. - 8+ years of relevant experience in preclinical drug discovery. - Proven track record in leading neuroscience programs to preclinical candidate nomination. - Expertise in neurobiology, in vivo pharmacology, and translational models of CNS disorders. - Strong leadership, communication, and project management skills. - Experience with IND-enabling studies, regulatory documentation, and biomarker discovery. - Proficiency in partnership management, publication record in high-impact journals, and hands-on experience with neurological animal models. Additional Company Details: This position operates in an office setting and requires in-person presence, with limited remote work. The job may also require availability outside regular hours for priority business needs. It is a largely sedentary role with no direct reports. Role Overview: As a critical member of the team, you will be responsible for driving the design, execution, and interpretation of preclinical studies to support the discovery and development of novel therapeutics for neurological disorders. Your expertise in neuroscience, pharmacology, and translational science will be instrumental in advancing drug candidates, including biologics and gene therapies, from early discovery through IND-enabling studies. Key Responsibilities: - Lead preclinical strategy and execution for neuroscience drug discovery programs. - Design and oversee in vivo and in vitro studies to evaluate pharmacodynamics, efficacy, and safety. - Guide target validation, biomarker development, and mechanism-of-action studies. - Serve as the preclinical lead on cross-functional project teams. - Collaborate with medicinal chemistry, DMPK, toxicology, and clinical teams for seamless transition from discovery to development. - Mentor and supervise a team of scientists and research associates. - Identify and manage CROs and academic partnerships for preclinical research support. - Contribute to the preparation of regulatory documents including INDs, IBs, and briefing packages. - Support IND-enabling studies and contribute to regulatory submissions. - Translate preclinical findings into clinical hypotheses and biomarker strategies. Qualifications: - Ph.D. in Neuroscience, Pharmacology, or related discipline; postdoctoral experience preferred. - 8+ years of relevant experience in preclinical drug discovery. - Proven track record in leading neuroscience programs to preclinical candidate nomination. - Expertise in neurobiology, in vivo pharmacology, and translational models of CNS disorders. - Strong leadership, communication, and project management skills. - Experience with IND-enabling studies, regulatory documentation, and biomarker discovery. - Proficiency in partnership management, publication record in high-impact journals, and hands-on experience with neurological animal models. Additional Company Details: This position operates in an office setting and requires in-person presence, with limited remote work. The job may also require availability outside regular hours for priority business needs. It is a largely sedentary role with no direct reports.
