Technician

Understanding how GSK3 controls neuronal development and maintenance in time and space GSK-3 is a key player during the formation and maintenance of neurons Over-activity has been linked to various neurodevelopmental and -degenerative diseases (e-g Alzheimer's and Parkinson's Disease, autism spectrum and mood disorders) making it a highly promising therapeutic drug target So far, therapeutic strategies manipulating GSK-3 have failed because their application was too general

In this project, we will pioneer the development of novel biosensors to explore GSK-3 activation and localised targeting of GSK-3 activity to study exactly when and where GSK-3 has to be active to influence neuronal development, and which regulators mediate this Gaining this refined understanding of GSK-3 will provide the foundations for improved therapeutic strategies This project is funded by a grant to Dr Ines Hahn (York), Dr Han-Jou Chen and Dr Peter OToole from BBSRC Role A description of the main duties and responsibilities of the job, as stated in the main purpose of the role and relevant key responsibilities in the job template (6-8 lines) The appointee will work in an active research lab, with other neuroscience groups including technicians and research students all working on a range of neurodegenerative problems They will provide technical and scientific support to a research project in a neuronal cell biology research laboratory, use molecular biology approaches to generate locally targeted GSK-3 variants, perform experiments using Drosophila primary neurons and maintain and generate Drosophila lines Skills, Experience & Qualification Needed Details of the main qualifications, knowledge, skills, experience and qualifications essential to the post (as stated in the 'person specificationin the job template) Interview date: To be confirmed The University strives to be diverse and inclusive a place where we can ALL be ourselves We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University