Reverse Phase chromatography

Job Title:

Executive / Analyst Reverse Phase Chromatography (RPC)

(23 Years Experience RP Chromatography Mandatory)

Job Summary:

We are looking for a skilled professional with23 years of hands-on experienceinReverse Phase Chromatography (RPC / RP-HPLC / RP purification)for bulk drug/API purification. The candidate will be responsible for operating chromatography systems, executing purification processes, and ensuring compliance with GMP guidelines.

Key Responsibilities:Chromatography Operations

• Perform

  Reverse Phase Chromatography (RP)

  for purification of APIs, intermediates, and bulk drug substances.
• Handle

  C18/C8 columns

  , mobile phase preparation, and gradient operations.
• Execute purification processes as per batch manufacturing records (BMR/BPR).

?Equipment Handling

• Operate and maintain

  prep chromatography systems

  (RP-HPLC / RP flash systems).
• Monitor equipment parameters, troubleshoot issues, and ensure smooth operation.
• Clean, sanitize, and maintain columns and chromatography instruments.

Process Execution

• Prepare mobile phases (wateracetonitrile, watermethanol, buffers).
• Monitor fractions, collect purified product, and perform in-process testing.
• Assist in scale-up and optimization of RP purification steps.

Documentation & Compliance

• Maintain batch records, logbooks, and purification data as per

  GMP

  .
• Follow SOPs, safety protocols, and quality procedures.
• Coordinate with QA, QC, and Production teams during audits and validations.

Team & Support

• Support process development and technical transfer activities.
• Work with senior chemists to improve yield and purification efficiency.

Required Skills:

• Mandatory:

  Strong hands-on experience in

  Reverse Phase Chromatography (RP)

  .
• Experience working with C18/C8 columns and gradient operations.
• Knowledge of RP purification principles and fraction collection.
• Understanding of GMP, safety, and documentation practices.
• Basic knowledge of RP-HPLC operation and troubleshooting.

Qualification:

• B.Sc / M.Sc (Chemistry), B.Pharm / M.Pharm
• 23 years of experience in

  API, Bulk Drug, or Pharmaceutical industry

Job Types: Full-time, Permanent

Benefits:

• Food provided
• Health insurance
• Provident Fund