Oligo Synthetic Chemist Syngene International Limited

3.0 - 7.0 years

0 Lacs

karnataka

On-site

As a Senior Research Associate at Syngene, you will be responsible for performing reactions according to project requirements and documenting observations accurately. Your role will entail independently handling automated oligo synthesizers, synthesizing DNA, RNA, ASOs, and modified oligonucleotides, and conducting conjugation using various reactions. You will be responsible for developing methods for purification and characterization of chemically modified oligonucleotides using analytical techniques such as HPLC, IEX, SEC, PAGE, LCMS, MALDI, and HRMS. Additionally, you will need to have hands-on experience with purification instruments like HPLC and AKTA-Pure. Critical thinking, scientific skills, and knowledge of oligonucleotide discovery processes are essential for this role. You should be a team player capable of planning and conducting scientific experiments from project initiation to completion. It is crucial to ensure that samples generated during synthesis are properly analyzed and recorded, and that instruments are well-maintained and calibrated. As part of your responsibilities, you must follow EHS and quality system requirements, attend mandatory trainings, and maintain confidentiality at all times. Flexibility to work in shifts and adherence to safety protocols and guidelines are mandatory. To qualify for this role, you should have 3-6 years of experience in oligo-synthesis, solid phase synthesis, and purification techniques. A background in MSc (Chemistry/Biochemistry/Biotech) with industrial experience is required. Your success in this role will depend on your deep knowledge of oligo synthesis concepts, ability to solve synthetic problems independently, and proficiency in purification and analytical interpretation skills. Familiarity with relevant apparatus and equipment operations is essential for carrying out your responsibilities effectively.,

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Executive - API R&D SUN PHARMA

3.0 - 7.0 years

0 Lacs

vadodara, gujarat

On-site

You will be responsible for executing activities related to R&D Peptide Process Development & Scale-ups, working alongside a team of Research Officers/ Research Assistants under the guidance of the Team/Group Leader. Your main tasks will include conducting literature searches and finalizing the Route of Synthesis, applying basic knowledge of Orthogonal protected amino acid and Peptide, performing Solid phase peptide Synthesis/Oligonucleodtide Synthesis, handling hazardous chemicals like Trifluoroacetic acid, managing analytical HPLC/Oligo Synthesis, purifying compounds using Preparative HPLC, packing and using preparative columns, and ensuring computer literacy. Additionally, you will need to have knowledge of Phosphoramidalin handling and storage. Specific duties will involve conducting literature searches for the assigned project and finalizing a non-infringing synthetic route, conducting experiments such as process development, DoE studies, optimization, and validation, purifying Peptide compounds, and being familiar with lyophilization processes. You will also handle analytical HPLC, prepare buffers, characterize Peptides using HRMS, 2D NMR, IR, Peptide mapping, and sequencing, prepare Technology transfer documents, scale-up processes developed at R&D, assist in filing DMF, and manage general laboratory operations. Overall, your role will be crucial in the successful execution of R&D Peptide Process Development & Scale-ups, contributing to the advancement of the team's projects and objectives.,

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