Oligo Synthetic Chemist

As a Senior Research Associate at Syngene, you will be responsible for performing reactions according to project requirements and documenting observations accurately. Your role will entail independently handling automated oligo synthesizers, synthesizing DNA, RNA, ASOs, and modified oligonucleotides, and conducting conjugation using various reactions. You will be responsible for developing methods for purification and characterization of chemically modified oligonucleotides using analytical techniques such as HPLC, IEX, SEC, PAGE, LCMS, MALDI, and HRMS. Additionally, you will need to have hands-on experience with purification instruments like HPLC and AKTA-Pure. Critical thinking, scientific skills, and knowledge of oligonucleotide discovery processes are essential for this role. You should be a team player capable of planning and conducting scientific experiments from project initiation to completion. It is crucial to ensure that samples generated during synthesis are properly analyzed and recorded, and that instruments are well-maintained and calibrated. As part of your responsibilities, you must follow EHS and quality system requirements, attend mandatory trainings, and maintain confidentiality at all times. Flexibility to work in shifts and adherence to safety protocols and guidelines are mandatory. To qualify for this role, you should have 3-6 years of experience in oligo-synthesis, solid phase synthesis, and purification techniques. A background in MSc (Chemistry/Biochemistry/Biotech) with industrial experience is required. Your success in this role will depend on your deep knowledge of oligo synthesis concepts, ability to solve synthetic problems independently, and proficiency in purification and analytical interpretation skills. Familiarity with relevant apparatus and equipment operations is essential for carrying out your responsibilities effectively.,