Discovery Chemistry

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Core Purpose of the Role:

Personnel handling this profile will be responsible for conducting reactions and delivering final compounds within a fast turnaround time, meeting the specific requirements of both the project and Syngene. The candidate should be capable of independently designing the synthetic scheme for any target and solve chemistry problems. He or she should ensure that the experimental observations are recorded contemporaneously and in compliance with the Electronic Laboratory Notebook (ELN) policies of the project and Syngene.

Role Accountabilities:

• Expected to design a synthetic scheme for any given target and to be proactive in identifying rate limiting steps along with the mitigation strategy.
• The candidate should be well versed in using literature search engines and predictive synthesis tools
• Perform synthetic chemistry reactions, reaction workups, purification of the compounds by column chromatography, crystallization, re-crystallization techniques, preparative TLC and operating lab equipments
• Ensure that the samples generated during synthesis are given for analysis and record subsequent results obtained and update the supervisor / group leader on the progress of synthesis and ensure samples are packed appropriately for shipment
• Record the observations of experiment/reaction, results, utilization of resources and other activities related to the reaction in the laboratory or e-notebook following guidelines and in timely manner and ensure that the same is handled safely and confidentially.
• The candidate should be capable of meeting Syngenes productivity expectations (# of compounds/month, # of steps/month and productivity index of around 1.5) without compromising on safety and quality.
• The candidate should be capable of synthesizing the final compounds at a faster turnaround time.
• The candidate should have excellent analytical interpretation and purification skills.
• Ensure that they know the SDS of the chemicals they are handling and aware of emergency response procedures in case of accidental spillage, leakage or fire and ensure proper waste segregation as per EHS norms.
• Always follow EHS and quality system requirements in the workplace ensuring individual safety and lab safety.
• Attend all mandatory trainings and update training records as and when trainings are completed.
• Always ensure confidentiality.

Specific requirements for this role

Experience

Skills and Capabilities:

• Should have deeper knowledge with concepts of organic synthesis and reaction mechanisms.
• Should be capable of designing synthetic schemes and troubleshooting synthesis problems independently.
• Should be excellent in purification and analytical interpretation skills.
• Familiar with operations of relevant apparatus - instrument / equipment.

Education: M.Sc. in organic chemistry