Associate Scientist

Designation: Associate Scientist / Senior Associate Scientist

Job Location: Bangalore

Department: TM-TDDT

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation .

Job Purpose (1-2 Lines)

We are seeking motivated master s level scientists (MS, MTech, MSc, etc) to join the Translational Medicine team at the Biocon Bristol Myers Squibb Research Center in Bangalore, India. Key responsibilities of this role are to serve as an execution arm for the preclinical support of asset programs through mechanism of action-based studies, differentiation from standard of care and competitive therapeutics, combination rationale, new indications (life cycle management), and patient selection strategies. S/He will work directly with translational scientists, disease leaders within translational medicine, and will also interact with thematic research centers in early development within the company.

Key Responsibilities:

• Conduct preclinical/laboratory experiments on late stage BMS portfolio compounds to support annual goals and objectives for Translational Medicine (for internal /external, collaborations, compound specific plans etc).


• Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation.


• Interfaces with TM scientists across departments to ensure seamless flow of information for assets which are entering the remit of translational medicine.


• Assists in designing experiments and delivering data for collaborative projects along with TM scientists.


• Maintains comprehensive records, communicates regularly and makes presentations within the department, as required.


• Reports experimental finding in written nonclinical pharmacology study reports, to support regulatory filings.

Educational Qualification:

Masters with at least 2 years of relevant work experience across immunology, oncology, heme-oncology focus areas. Industry experience is a plus. Multiple positions can range upto 6 years of experience.

Technical/functional Skills:

• Cell culture, primary cell isolation, cell transfection and single cell cloning; including siRNA / CRISPR / TALEN or HDR workflows


• Gene expression methods including qRT-PCR and/or familiarity with RNA sequencing, epigenomic methods including methylation analysis, ChIP etc


• Protein analyses and immunoassays, and cell phenotyping analysis (e. g. ELISA, MSD, Luminex, TSA, CBA, flow cytometry).


• Design, setup and execution of autoimmune, solid tumor oncology or heme-oncology in vivo pharmacology models.


• Excellent verbal and written communication skills, familiarity with standard or relevant software platforms, and scientific qualities are expected.


• Competence in analysis and solving of problems, keeping track of overall goals.


• Maintain a good understanding of the methodological basis and biological significance of assays performed.


• Forecast potential issues regarding support of assays for current and long term projects.


• Devise strategic solutions to identified and potential hurdles/issues and efficiently and proactively troubleshoot technical and experimental problems.

Experience:

2-6 years

Behavioral Skills:

• A self-starter, who is/can become technically proficient in a diverse set of techniques and assays with a focus on quality and speed, and will meticulously follow internal SOPs


• Good basic lab skills required (pipetting, balances, etc. )


• Highly detailed and meticulous, high standards of data entering and QC


• Must be highly adaptive to changing timelines and goals


• Must be comfortable taking on complex tasks with minimal direct supervision


• An excellent multitasker with an ability to be level-headed in a fast-paced lab setting


• Team-oriented and comfortable working in a highly dynamic matrix environment across multiple locations


• Prior experience working with patient samples (i. e. FFPE tissue, Fresh Frozen tissue, blood) or working in a CLIA/GCLP/clinical environment is a plus


• Must be comfortable and able to work with animal (rodent) or human derived samples

Equal Opportunity Employer:

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