4 Prep Hplc Jobs

Dear Candidate, We are conducting walk-in drive on 06th June (Friday) for the positions in our Analytical Research & Development department. Job Description : Position Name: Senior Research Chemist/Research Associate Experience: 2 to 5 years Qualification: M.Sc Analytical Chemistry/Organic Chemistry Work location: Uppal/Mallapur Walk-in Date: 06th June 2025 (Friday) Time: 09:00 AM to 12.00 PM Venue:-Plot No. B-11/1,,,IDA Uppal,Hyderabad Key Skills and Competencies: Must have strong hands-on experience in development and validation of Assay & related substances methods for drug substance/drug product. • Must have experience in handling HPLC, UPLC (Empower-3 software), GC, UV Visible spectrophotometer balances, Potentiometer, and stability chambers • Shall have experience on Good documentation/laboratory practices such as ALCOA+ Experience in calibration and qualification of HPLC, UPLC, GC, and other QC laboratory instruments • Shall prepare and review the raw data sheets, instrument operating procedures, and standard operating procedures • Shall have good experience in handling of QMS (such as incidents, Out of Specifications, Deviations, and Change control) Interested candidates can attend walk-in drive or share their profiles to saivardhan.kothuri@chemvedals.com

Role & responsibilities 1. Analytical Testing and Analysis : a. Analyze samples from various sources (raw materials, intermediates, finished products, and stability samples) to determine compound composition and quantities. b. Perform routine and complex analyses using HPLC, Prep HPLC, LCMS, UPLC, and Flash chromatography. c. Interpret analytical data and provide comprehensive reports of scientific results, including trend analysis and data summaries. d. Conduct testing, release, and documentation of raw materials, intermediates, and finished products, adhering to established specifications. e. Perform stability studies and analyze degradation products. 2. Method Development and Validation: a. Develop and validate HPLC, LCMS, and other analytical methods for various drug products and chemical compounds, including forced degradation studies. b. Ensure methods are robust, reliable, and compliant with regulatory requirements (ICH guidelines, etc.). c. Write and review method validation protocols and reports. 3. Instrument Management and Documentation: a. Perform routine calibration, maintenance, and troubleshooting of HPLC, LCMS, GC, and other analytical instruments. b. Prepare and maintain Standard Operating Procedures (SOPs) and Instrument Operating Procedures (IOPs). c. Maintain accurate and detailed documentation of all analytical activities, including raw data, instrument logs, and reports, in accordance with GLP/GMP. d. Participate in instrument qualification. 4. Quality Control and Compliance: a. Ensure all analytical activities comply with established quality control procedures and regulatory guidelines. b. Maintain awareness of and adhere to health and safety regulations, including chemical handling and waste disposal. c. Validate methods and equipment to ensure accuracy and reliability, participating in audits as needed. d. (Optional) Ensure compliance with cGMP and GLP guidelines. e. Participate in investigations of out-of-specification (OOS) results. 5. Collaboration and Communication: a. Work collaboratively in cross-functional teams, including R&D, formulation, and regulatory affairs. b. Liaise with customers, staff, and suppliers as needed. c. Report scientific results effectively to stakeholders, including presentations and written reports. d. Participate in project meetings. Preferred candidate profile Technical Skills: a. Extensive hands-on experience with HPLC, Prep HPLC, LCMS, UPLC, and Flash chromatography. b. Proven experience in developing and validating HPLC and LCMS methods. c. Knowledge of instrument calibration, maintenance, and troubleshooting. d. Proficiency in data interpretation, statistical analysis, and documentation. e. Knowledge of stability testing. Knowledge: a. Strong understanding of analytical chemistry principles and techniques. b. Knowledge of raw materials, intermediates, finished product, and stability testing. c. Knowledge of preparing SOPs, IOPs, validation protocols, and reports. d. Knowledge of regulatory guidelines (ICH, etc.). e. (Optional) Knowledge of cGMP and GLP compliance. Soft Skills: a. Excellent analytical and problem-solving skills. b. Strong attention to detail and ability to maintain meticulous records. c. Excellent communication skills (both written and verbal). d. Proficiency in Microsoft Office Suite (Word, Excel, PowerPoint). e. Ability to work independently and manage multiple tasks effectively. f. Strong team player Key Attributes: a. Accuracy and reliability in analytical work. b. Commitment to quality, compliance, and safety. c. Proactive and adaptable to new challenges and technologies. d. Strong organizational and time-management skills. e. Ability to learn and keep up to date with new analytical techniques and regulatory requirements. f. Ethical conduct. Perks and benefits

Key Responsibilities: Strategic Actively imbibing the values and philosophy of PI Industries. Efficient contribution to the overall success of product innovation (PRI) through scientific contribution to objectives and targets being set by the leadership team. Fullfilling requirements and achieveing goals set by the Team Leader and Group Leader Working as a team member, contributing to the team objective with special focus on achiving and exceeding the set target. Development of individual & team strengths by attending trainings based on the regular feedback as an individual and as a team Operational Monitoring reaction masses using LCMS/GCMS. Execution of purity assessment and assay determination of samples using GC/HPLC/UFLC. Able to carry method development for challenging compounds through GC/GCMS/HPLC/UFLC Developing methods on Prep HPLC for purification/isolation of impure compounds. Elucidating and confirming structures using NMR, FTIR and LCMS/MS Ensure the scheduled performance of calibrations, Preventive maintenance and troubleshooting of core analytical instrument. Following the set instrument maintenance practices like periodic solvent changes, system flushing, etc. Assist the other team members in day to day activities like sample preparation, method developments, report generation and data management. Following safety practices with out fail. Financial Planning the activities with existing resources and infra structure. Suggesting the cost-effective areas to the Team Leader / Group Leader Developing methods to improve the environment safety and to reduce the cost. People Collaborate with team members and cross functional teams to meet research objectives. Develop and foster positive relationships with other teams and support groups to maximize cooperation and consequent benefit to objective delivery Should be able to work in multitasking environment Ensure team harmony through collaboration and active participation in all team discussion Apart from the above responibilities, specific responsibilities of Research scientists Note : The Associate would in any of the areas listed below based on the requirement and should have sufficient knowledge and expertise in the area alloted as listed below 1. HPLC/UFLC Candidate should be well versed with normal and reverse phase chromatography techniques. Able to optimize chromatographic methods Keen knowledge on low level analyte-impurities quantification by HPLC. 2. LCMS SQD & TQD Well versed with operations of one or more makes of LCMS-SQD & TQD instruments. Aware of basic principles related to mass spectrometry, sources, analysers and detectors. Hands on experience in analysis of compounds using LCMS instrument and releasing the mass confirmation reports. Keen knowledge on ppb / ppm level quantification of analytes from AI, formulations, various matrices like microsomes, soil, plant extracts by LCMSMS. Perform possible structural elucidation/Identification of degradants/metabolites/impurities using LCMS/MS 3. NMR Perform suitable 1D/2D NMR experiments based on the requirement and confirm one among proposed structures or propose a new structure. Manage the NMR activities viz, perform routine NMR (1D&2D) analysis, QNMR, cryogen replenishing. Keen knowledge of NMR technology & instrument maintenance. 4. Physchem assays Have hands on knowledge of various in vitro ADME/ physchem assays like solubility, LogP, pKa and in vitro Metabolic stability assay. Able to develop methods, check method compatibility for accuracy, precision, matrix effect and apply it further for the quantification of formulations, plant extracts, various matrices like soil, microsomes etc. Perform the microsomal stability experiments to determine half-life and Clint. Awareness about Met ID using various scans, fragmentation tree & HRMS will be an added advantage. Knowledge about sample preparation and analysis of photo stability and hydrolytic stability. 5. Prep-HPLC Able to develop a robust chromatographic method both at analytical and preparative scale, by designing cost effective methods for chiral and achiral molecules. Knowledge of chiral chromatography and isolation of enantiomers using preparative HPLC. Please share updated resume on e-mail id Shubhi.chandnani@piind.com

Key Responsibilities Need to have strong theoretical knowledge (HPLC/LCMS/Prep.HPLC/SFC) Plan and conduct the analysis with required skills. Record the observations meticulously and update to the TL/SME. Share and discuss the observations with supervisor. Independent in maintaining the instrument and setting up the instrument for analysis. Expected to be aware of basics in analytical chemistry (basic analytical techniques Theory and application) as well as handling of laboratory equipment / instruments with basic understanding. Expected to be aware and working in a safety compliant manner