Senior Scientist, Clinical PBPK Modeling AstraZeneca

0.0 - 4.0 years

0 Lacs

karnataka

On-site

As a Senior Scientist in Clinical PBPK Modeling at AstraZeneca, located in Bengaluru, Karnataka, India, you will play a crucial role in advancing clinical drug development through the application of innovative and quantitative approaches. Your primary responsibility will involve utilizing physiologically-based pharmacokinetic (PBPK) and translational modeling tools to facilitate clinical PK projections for drug-drug interactions (DDIs), pediatric and specific populations, and other critical clinical development inquiries. Collaboration with Drug Metabolism and Pharmacokinetic (DMPK) Scientists, as well as Clinical Pharmacology scientists, will be key in generating mechanistic models. Your expertise will be pivotal in validating these models to a level suitable for Regulatory submissions and influencing the design of clinical trials. Furthermore, effective communication internally and externally on topics related to PBPK clinical DDI, pediatric, and other specific populations predictions will be essential. To excel in this role, you should possess knowledge of pharmacokinetics, Model-Informed Drug Development (MIDD), and have demonstrated experience in translational development, preferably with 0-4 years of drug development experience focusing on PBPK modeling. Additionally, familiarity with pharmacology, drug targets, and core disease areas is required. A Ph.D. degree or equivalent (M.Sc./Pharm.D.) with relevant experience is preferred. Proficiency in spoken and written English, along with training and experience in PBPK and relevant software such as SimCYP, GastroPlus, PK-Sim, and Phoenix WinNonlin, is necessary. Desirable skills include a strong scientific publishing reputation in the field of DMPK/Clinical Pharmacology and experience in early and late-stage drug development. By being a part of our diverse and inclusive team, you will have the opportunity to contribute to groundbreaking discoveries that have the potential to transform lives. If you are ready to make a significant impact in the field of clinical PBPK modeling, we invite you to apply now and embark on this exciting journey with us at AstraZeneca.,

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