4 Human Genetics Jobs

What We Want You To Do Analyze and manage the NGS / Nanopore data using relevant pipelines. Develop customized pipelines and workflows and tweak current pipeline filters for NGS and Nanopor analysis Help in developing and executing various data management strategies Identify the databases, tools, catalogs, and their reliability in future and help the research team in data collection strategies. Interpret genetic sequence variations identified through the pipelines Check quality and accuracy of the data Work in conjunction with team members to ensure consistent result generation Work in conjunction with wet lab and tech teams to ensure smooth operations and development work Troubleshoot issues related to data analysis tools and software Review literature for new technologies in the field of Bioinformatics Write grants and papers in the company Creating documentation and maintaining it What Are We Looking In You PhD in Genetics/Genomics or related fields or 8+ years of experience in the field of human genomics/genetics Experience with building bioinformatics pipelines for various kinds of NGS data Assisting in drafting and completing manuscripts for publication Experience with handling various different databases and tools Perform statistical analysis on the datasets Comfortable working on Linux OS system Ability to read, interpret and curate scientific literature Excellent communication skills (oral and written) and attention to detail Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow, instructions, complete deadlines, and comply with company policies Experience of 1-2yrs+ in Python & experience of 3-5 yrs in Bash scripting Experience with pipeline orchestration tools (Nextflow or Snakemake) will be a bonus

What We Want You To Do Analyze and manage the NGS / Nanopore data using relevant pipelines. Develop customized pipelines and workflows and tweak current pipeline filters for NGS and Nanopor analysis Help in developing and executing various data management strategies Identify the databases, tools, catalogs, and their reliability in future and help the research team in data collection strategies. Interpret genetic sequence variations identified through the pipelines Check quality and accuracy of the data Work in conjunction with team members to ensure consistent result generation Work in conjunction with wet lab and tech teams to ensure smooth operations and development work Troubleshoot issues related to data analysis tools and software Review literature for new technologies in the field of Bioinformatics Write grants and papers in the company Creating documentation and maintaining it What Are We Looking In You PhD in Genetics/Genomics or related fields or 8+ years of experience in the field of human genomics/genetics Experience with building bioinformatics pipelines for various kinds of NGS data Assisting in drafting and completing manuscripts for publication Experience with handling various different databases and tools Perform statistical analysis on the datasets Comfortable working on Linux OS system Ability to read, interpret and curate scientific literature Excellent communication skills (oral and written) and attention to detail Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow, instructions, complete deadlines, and comply with company policies Experience of 1-2yrs+ in Python & experience of 3-5 yrs in Bash scripting Experience with pipeline orchestration tools (Nextflow or Snakemake) will be a bonus Skills: pipelines,pipeline orchestration tools (nextflow, snakemake),python,genomics,communication skills,bash scripting,ngs data analysis,linux,quality control,bioinformatics pipeline development,ngs,nanopore data analysis,genetics,literature review,bioinformatics pipelines,linux os,pipeline orchestration tools (nextflow or snakemake),grant writing,statistical analysis,genetic sequence interpretation,scientific literature interpretation,human genetics,bioinformatics,data management strategies,pipeline

What We Want You To Do Analyze and manage the NGS / Nanopore data using relevant pipelines. Develop customized pipelines and workflows and tweak current pipeline filters for NGS and Nanopor analysis Help in developing and executing various data management strategies Identify the databases, tools, catalogs, and their reliability in future and help the research team in data collection strategies. Interpret genetic sequence variations identified through the pipelines Check quality and accuracy of the data Work in conjunction with team members to ensure consistent result generation Work in conjunction with wet lab and tech teams to ensure smooth operations and development work Troubleshoot issues related to data analysis tools and software Review literature for new technologies in the field of Bioinformatics Write grants and papers in the company Creating documentation and maintaining it What Are We Looking In You PhD in Genetics/Genomics or related fields or 8+ years of experience in the field of human genomics/genetics Experience with building bioinformatics pipelines for various kinds of NGS data Assisting in drafting and completing manuscripts for publication Experience with handling various different databases and tools Perform statistical analysis on the datasets Comfortable working on Linux OS system Ability to read, interpret and curate scientific literature Excellent communication skills (oral and written) and attention to detail Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow, instructions, complete deadlines, and comply with company policies Experience of 1-2yrs+ in Python & experience of 3-5 yrs in Bash scripting Experience with pipeline orchestration tools (Nextflow or Snakemake) will be a bonus

Position: Research Associate (RA) for Gene Editing Project Overview: Human stem cell differentiation technology enables the generation of any cell or tissue in the body, leveraging human-origin cells for their easy accessibility and scalability. Recent advances in gene editing, particularly CRISPR-Cas technology, are revolutionizing the generation of human pluripotent stem cell-based experimental platforms to model "disease in a dish." In this role, you will advance research on neurological diseases by utilizing CRISPR/Cas technology to introduce disease-causing mutations in human pluripotent stem cell (iPSC) lines. Additionally, you will develop gene-targeting strategies for direct pluripotent stem cell differentiation into enriched cultures of neurons, astrocytes, and oligodendrocytes, using inducible gene expression systems (optogenetic and chemical methods) (Sheta etal. ,2023;Teixeira etal. ,2023). Furthermore, you will be involved in generating isogenic (gene-corrected controls) pluripotent stem cell lines against patient pluripotent stem cell lines (Banerjee etal. ,2023). The candidate will play an integral role in projects related to development, optimization of new gene editing tools. Collectively, candidates should have an expertise and interest in CRISPR-Cas technology for generating cellular models recapitulating neurological diseases. Essential Requirements: Educational Background: MSc/PhD in a relevant field, with around 3-5 years of experience in gene editing and molecular biology Genome Editing Expertise: Demonstrated proficiency in creating knock-out/knock-in lines utilizing CRISPR/Cas technology. The ideal candidate should have a publication record that showcases their expertise in gene editing. In-depth knowledge of the latest advancements in gene editing technologies is essential for this role. Technical Proficiency: Skilled in using genome browsers, DNA analysis software, and CRISPR/Cas related on/off target specificity analysis, primer design, designing guides, molecular cloning Cellular Characterization Techniques: Proficient in immunofluorescence staining, FACS analysis, and PCR Team Collaboration: Demonstrated ability to contribute effectively to a team with a collaborative and flexible approach Project Management: Strong independent work ethic with excellent project planning, time-keeping, organizational, and online record-keeping skills in electronic lab-books Health and Safety: Understanding of health and safety requirements related to genetic engineering of cell lines Professional Development: Commitment to continued professional development. Communication Skills: Excellent oral and written communication skills, capable of conveying complex information through power point presentation Interpersonal Skills: Strong interpersonal skills to influence and deliver results Desired additional qualifications: iPSC Experience: Experience in gene-editing of pluripotent stem cells or mammalian cell lines to generate stable lines Neurobiology basics: Understanding of the functions of brain cells and their relevance to neurological diseases Knowledge on Sequencing: Familiarity with Sanger sequencing. Viral Vector Generation: Experience in generating viral vectors for labelling cells, regulating gene expression, and manipulating cell physiology CRISPR screening Relevant references Banerjee, P. et al. (2023) Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration., Science Advances , 9(16), p. eabq0651. doi:10.1126/sciadv.abq0651. Sheta, R. et al. (2023) Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons.,” STAR Protocols , 4(3), p. 102486. doi:10.1016/j.xpro.2023.102486. Teixeira, M. et al. (2023) “Optogenetic-mediated induction and monitoring of -synuclein aggregation in cellular models of Parkinson’s disease.,” STAR Protocols, 4(4), p. 102738. doi:10.1016/j.xpro.2023.102738.