2 Ba Studies Jobs

Job Title: Invitro BA Scientist Job Location: Bangalore, Hyderabad' About Syngene : Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit Mandatory expectation for all roles as per Syngene safety guidelines • Overall adherence to safe practices and procedures of oneself and the teams aligned • Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards • Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. • Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. • Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self • Compliance to Syngene s quality standards at all times • Hold self and their teams accountable for the achievement of safety goals • Govern and Review safety metrics from time to time Core Purpose of the Role : • To participate in sample processing for PK, ADME assays and handling of LCMS/MS. Ability to adapt to the dynamic team environment • Processing of different matrices samples of PK studies • Optimization of test compounds manually as well as automated on LCMS/MS • Develop methods with the team lead • Independently handling of HPLC for UV based samples analysis. • Documenting the lab note books online and compound management Syngene Values All employees will consistently demonstrate alignment with our core values ' Excellence Integrity Professionalism Experience 3- 10+years Education : Msc/Pharm/Mtech/Phd/ Fresh phd with relevant exp during academics or any postdoc Skills and Capabilities • Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory • Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods • Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis • Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required • Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra • Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff • General understanding of Drug metabolism and Pharmacokinetics • Should be able to deliver scientific presentation in departmental journal club and write official Project reports

Job Title: Invitro ADME Job Location: Bangalore/Hyderabad About Syngene Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit. Mandatory expectation for all roles as per Syngene safety guidelines Overall adherence to safe practices and procedures of oneself and the teams aligned. Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards. Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self. Compliance to Syngene s quality standards at all times. Hold self and their teams accountable for the achievement of safety goals Govern and Review safety metrics from time to time Job Purpose Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines. Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping Adhere to all safety rules and maintains safe workplace. Predominantly laboratory-based job Experience: 3- 10+years Education: Msc/Mpharm/Mtech/Phd/ Fresh phd with relevant exp during academics or any postdoc Key Responsibilities: Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Technical/functional Skills: Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism Demonstrated cross functional leadership capabilities Experience with automation is desirable Behavioral Skills: Demonstrate ability to be a team player. Commitment to deliver the study reports within the agreed timelines Adaptability to changes in the dynamic lab environment Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.