4 Animal Models Jobs

As a Biology Lead NCE Drug Discovery Scientist at Morepen Proprietary Drug Research Pvt. Ltd. (MPDRPL) in Hyderabad, India, you will play a crucial role in advancing New Chemical Entities (NCEs) through invitro and invivo preclinical biology studies. Your responsibilities will include guiding a biology team, overseeing the development of assays, conducting binding assays, and contributing significantly to the drug discovery process. Your key responsibilities will involve leading the development and optimization of various assays such as biochemical, cell-based, cytotoxicity, and ex-vivo assays for screening molecules targeting different drug targets across multiple therapeutic areas. You will also be responsible for identifying and validating biomarkers, managing collaborations with external partners, reviewing preclinical studies, proposing novel drug targets, and handling project planning, budgeting, and regulatory filings. To qualify for this role, you should ideally possess a PhD or Master's degree in Biology, Pharmacology, or a related field, along with 6+ years of experience for PhD holders or 10+ years of experience for Master's degree holders in drug discovery and preclinical biology. Strong expertise in assay development, biomarker identification, managing outsourced research, regulatory filings, and project management is essential. Additionally, proficiency in various technical skills such as preclinical assay platforms, AI/ML applications, drug discovery processes, animal models, and regulatory documentation is required. Soft skills such as exceptional leadership, team-building, analytical thinking, problem-solving, and effective communication are crucial for this role. Your ability to collaborate across multidisciplinary teams and external partners will be essential in driving the success of NCE development projects at MPDRPL. In summary, as the Biology Lead NCE Drug Discovery Scientist at MPDRPL, you will be at the forefront of innovative drug discovery, playing a pivotal role in advancing NCEs that address unmet medical needs across various therapeutic areas. Your expertise, leadership, and collaborative skills will be instrumental in driving the success of preclinical biology studies and contributing to the growth and development of the Biology team.,

You get to collaborate on: Work closely with discovery specialists, disease area scientists and in vivo team members. Handling of laboratory animals like rat, mice, Guniea Pig and Rabbits. Dose administration to experimental animals by different routes and small animals surgery (like cannulations, CSF fluid collection) and handling, followed by compound dose preparation, administration to experimental animals. Contributing to the ongoing drug discovery programs by conducting in vivo DMPK studies for NCEs with a good knowledge of in vivo animal models. Data generation, analysis, compilation, report preparation. Regular uploading of the data. Conduct statistically supported data (analysis using win online) and deliver results in a timely manner to enable informed decision-making Understanding systems, processes, and compliance. Prepare, review, and deliver scientific presentations for internal/external use. Participate in cross-functional team activities, add value to research projects through creative ideas. Learn from top-notch drug discovery scientists across the world and opportunity to get trained in people skills. PK-PD studies in rat and mice of NCE.

Are you a medical graduate or post-graduate with a passion for research If the clinical challenges excite you and you are eager to delve into new knowledge about health and diseases, including the discovery of rare diseases, then this Ph.D. opportunity might be the perfect fit for you. The Clinical Research Training Programme (CRTP) for rare diseases is designed to equip physicians with the necessary skills to navigate the complex landscape of rare genetic diseases. These diseases often lack effective treatments and impose a heavy burden on patients and their families. By participating in this program, you will have the chance to earn a Ph.D. degree upon completion and become a multi-domain expert capable of bridging the gap between patient care and cutting-edge research in the field of rare genetic diseases. Eligible candidates include post-graduates and graduates in Medical or Dental Sciences with qualifications such as DM, MCh, MD, MS, MBBS, or their equivalents. This program is a collaborative effort between Manipal Academy of Higher Education, Manipal, Institute of Bioinformatics, Bengaluru, and Dr. Reddys Institute of Life Sciences, Hyderabad. It is supported by funding from the DBT Wellcome Trust India Alliance. The program spans 3-4 years and offers comprehensive training in basic science research for physicians. You will gain hands-on experience in various research techniques such as handling samples, sequencing, data analysis, molecular biology, cell culture, animal models, systems biology, and exposure to drug development in both clinical and laboratory settings. The first year of training will take place at MAHE, Manipal, followed by training at MAHE or other participating institutions, with opportunities for international training with collaborators abroad. Mentorship will be provided by approved Ph.D. guides from MAHE, Institute of Bioinformatics, and Dr. Reddys Institute of Life Sciences. Additionally, students will have the chance to learn from international collaborators at renowned institutions around the world. Each candidate will receive a budget of Rs. 50,00,000 to cover salaries, research expenses, and travel. There are six fellowships available, and successful candidates may have the opportunity for permanent positions at the host institution upon completion of the program. To apply, interested candidates can submit their CV and a statement of interest explaining their passion for research and the program to jobs.research@manipal.edu. Join us on this exciting journey to explore the world of rare diseases and make a meaningful impact on healthcare and research!,

Role & responsibilities Collaborates with field experts in Research and Pre-Clinical Development to plan, execute and analyze relevant experiments independently, notably design of experiments feasible under given lab conditions, support of sample-size calculations and application for animal testing licenses, randomization, data transfer into appropriate stats software, interpretation of results. Takes statistical responsibility for one or more standard experiments. Develops the statistical analysis plan for the experiments as appropriate, ensuring overall consistency within and between projects. Facilitates the overall organization and coordination of statistical activities for specific experiments and small projects. Leads virtual cross-functional sub-teams within NCS/SIS of DS&AI. Assumes responsibility for the production and accuracy of the statistical deliverables and interpretation of the results. Works independently at routine and complex statistical questions and tasks. Develops and implements standard processes for the analysis of routine experiments. Oversees and ensures accurate and timely delivery of statistical work outsourced to external providers. What we're looking for Qualifications & Competencies: PhD or MSc in Biostatistics, Statistics or Mathematics, or related field. Strong communication skills. Ability to work independently as well as collaboratively, as required. Ability to translate statistical results into biological meaning Good knowledge of statistical programming languages (including SAS and R). Fluent English skills. At least two years as a non-clinical statistician focused on in vivo and in vitro experiments with significant time spent in pharma, biotech or similar sector.