4 Adme Assays Jobs

Date: 3 Sept 2025 Location: Bangalore, KA, IN, 560099 Custom Field 1: Discovery Services Job Title: in-vitro Bioanalytical Scientist Job Location: Bangalore About Syngene : Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit Mandatory expectation for all roles as per Syngene safety guidelines Overall adherence to safe practices and procedures of oneself and the teams aligned Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self Compliance to Syngene s quality standards at all times Hold self and their teams accountable for the achievement of safety goals Govern and Review safety metrics from time to time Core Purpose Of The Role To participate in sample processing for PK, ADME assays and handling of LCMS/MS. Ability to adapt to the dynamic team environment Processing of different matrices samples of PK studies Optimization of test compounds manually as well as automated on LCMS/MS Develop methods with the team lead Independently handling of HPLC for UV based samples analysis. Documenting the lab note books online and compound management Syngene Values All employees will consistently demonstrate alignment with our core values Excellence Integrity Professionalism Accountabilities as a Syngene Leader (only for Leadership Hires) Champion effective Environment, Occupational Health, Safety and Sustainability (EHSS) practices for the company and oversee compliance with those practices within Biologics business. Play an active leadership role in monitoring and verifying safety performance through Gemba walks and other safety-led activities. Foster a corporate culture that promotes an environment, occupational health, safety, and sustainability (EHSS) mindset as well as the highest standards of quality, integrity, and compliance. Put people at the heart of our success by providing clear, active leadership defined by the Syngene leadership framework setting high standards of people management, career planning and talent retention as a priority. Experience Minimum 1-3 years of experience in handling ADME assays and HPLC and LCMS/MS Skills And Capabilities Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff General understanding of Drug metabolism and Pharmacokinetics Should be able to deliver scientific presentation in departmental journal club and write official Project reports Education M. Pharm in Pharmaceutical sciences, Pharmaceutical Analysis who has interest and passion for LC/MS related bioanalysis Equal Opportunity Employer It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodation for qualified individuals with disabilities. Show more Show less

Date: 28 Jul 2025 Location: Bangalore, KA, IN, 560099 Custom Field 1: Discovery Services Job Title: In-vitro Bioanalytical Scientist Job Location: Bangalore About Syngene : Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit Mandatory expectation for all roles as per Syngene safety guidelines ? Overall adherence to safe practices and procedures of oneself and the teams aligned ? Contributing to development of procedures, practices and systems that ensures safe operations and compliance to companys integrity & quality standards ? Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. ? Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. ? Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self ? Compliance to Syngene s quality standards at all times ? Hold self and their teams accountable for the achievement of safety goals ? Govern and Review safety metrics from time to time Core Purpose Of The Role ? Client facing, scientific leadership role your main responsibility will be to provide expert DMPK support to multidisciplinary integrated Drug Discovery projects ? Defining and implementing the DMPK strategy to expedite project progression. ? Participate in various capability building projects as per business requirements ? The candidate will be responsible for providing input into the design of experimental protocols and Bioanalytical procedures for the analysis of drug candidates in biological samples ? Should deliver scientific presentation in departmental journal club and write official Project reports Role Accountabilities ? Plan and supervise routine Bioanalytical work flow to ensure deliverables/ productivity, along with verification of analytical study data for its accuracy and integrity. ? Mentor and supervise fellow scientists for method development and troubleshooting for routine as well as critical Bioanalytical work ? The candidate should be able to troubleshoot LC-MS/MS based bioanalytical methods and he should play key role in evaluation/interpretation of bioanalytical results. ? Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra ? Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff ? General understanding of Drug metabolism and Pharmacokinetics Leadership Capabilities ? People management ? Strong communication skills ? Team building ? Good communication ? Strong problem solving attitude ? Reasonable Interpersonal skills Syngene Values All employees will consistently demonstrate alignment with our core values ? Excellence ? Integrity ? Professionalism Accountabilities As a Syngene Leader (only For Leadership Hires) ? Champion effective Environment, Occupational Health, Safety and Sustainability (EHSS) practices for the company and oversee compliance with those practices within Biologics business. Play an active leadership role in monitoring and verifying safety performance through Gemba walks and other safetyled activities. ? Foster a corporate culture that promotes an environment, occupational health, safety, and sustainability (EHSS) mindset as well as the highest standards of quality, integrity, and compliance. ? Put people at the heart of our success by providing clear, active leadership defined by the Syngene leadership framework setting high standards of people management, career planning and talent retention as a priority. Experience Minimum 10-15 years of relevant industry Demonstrated Capability ? Collaboration ? Leading Team ? Bioanalytical Excellence Education M. Pharm in Pharmaceutical sciences, Pharmaceutical Analysis with, Minimum 10 years of experience in handling ADME assays and HPLC and LCMS/MS Or Fresh Ph D in similar disciplines Equal Opportunity Employer It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities. Show more Show less

As an In vitro Bioanalytical Scientist at Syngene, based in Hyderabad, you will be responsible for participating in sample processing for PK and ADME assays, as well as handling LCMS/MS. Your role will involve adapting to a dynamic team environment, processing various matrices samples for PK studies, optimizing test compounds manually and automated on LCMS/MS, and independently handling HPLC for UV-based sample analysis. Additionally, you will be expected to develop methods with the team lead, document lab notebooks online, and manage compounds effectively. You will need to demonstrate expertise in column selection, mobile phase selection, solvent preparations, and sample processing techniques such as protein precipitation, liquid-liquid extraction, and solid-phase extraction. It is essential to have experience in handling ADME assays and HPLC and LCMS/MS, with a minimum of 3-5 years of relevant experience. Moreover, you should be capable of developing and validating LC-MS based qualitative/quantitative methods, conducting internet-based literature searches, and interpreting Mass/UV Spectra. As a part of the Syngene team, it is mandatory to adhere to safety guidelines, procedures, and SOPs, ensuring the safety of yourself, teams, and the lab/plant at all times. You must also complete all assigned mandatory trainings related to data integrity, health, and safety measures promptly. Furthermore, you will be expected to comply with Syngene's quality standards, hold yourself and your teams accountable for safety goals, and review safety metrics periodically. Syngene values excellence, integrity, and professionalism, and expects all employees to consistently demonstrate alignment with these core values. As a leader at Syngene, you will champion effective Environment, Occupational Health, Safety, and Sustainability (EHSS) practices, foster a corporate culture promoting an EHSS mindset, and uphold the highest standards of quality, integrity, and compliance. The ideal candidate for this role should possess a M. Pharm in Pharmaceutical Sciences or Pharmaceutical Analysis with a passion for LC/MS related bioanalysis. You should have a general understanding of drug metabolism and pharmacokinetics, be able to deliver scientific presentations, and write official project reports. Additionally, you should ensure preventative maintenance and calibration schedules of HPLC and mass spec by coordinating with vendors and support staff. Syngene is an equal opportunity employer, committed to providing integrated scientific services from early discovery to commercial supply, with safety as a top priority in all aspects of operations.,

Job Title: Invitro ADME Scientist Location: Bangalore/Hyderabad Job Purpose Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines. Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping Adhere to all safety rules and maintains safe workplace. Predominantly laboratory-based job Key Responsibilities: Extensive experience in planning metabolic stability, CYP inhibition assays Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes. Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies. Preparation of SOPs and EOPs. Reporting of executed studies without any noncompliance. Reporting of study results clearly in the cross functional scientific meetings. Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety. Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team. Technical/functional Skills: Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism Demonstrated cross functional leadership capabilities Experience with automation is desirable Experience: A M Pharm. in pharmaceutical sciences or M SC in biological science with three or more years of Industrial experience in DMPK/ADME research. PHD with relevant experience in DMPK/ADME research Behavioral Skills: Demonstrate ability to be a team player. Commitment to deliver the study reports within the agreed timelines Adaptability to changes in the dynamic lab environment Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.