Job
Description
Position Upstream Scientist , Role Description As an Upstream Scientist , you will be responsible for planning and execution of experiments, analyzing data and preparing reports. Your contribution will be critical in advancing our vaccine programs. Candidate must be able to Design and execute process development studies to develop a thorough understanding of operating and performance parameters Perform hands on work in a cell culture lab, specifically cell culture expansion (insect as well as mammalian systems, adherent/ suspension), cell bank preparation, bioreactor operation in fed-batch and perfusion modes, optimization of media components, feeding control strategy Lead activities of vaccine production as well as process scale up with proper method development reports. Perform and analyse Design of Experiment (DOE) studies to develop or optimize processes to ensure a phase-appropriate, consistent, high-yielding and scalable upstream process from shake-flask to 200L scale bioreactor. Support in PPQ activities and scale-down model establishment, Support process characterization studies and tech transfer process. As needed, support process validation, including validation protocol writing, execution and report writing. Ability to think critically, demonstrate troubleshooting and problem-solving skills. Communicate with internal and external stakeholders through meetings and clearly written emails, reports, and presentations. Identify and leverage external capabilities that complement internal core competencies. Review and apply learnings from academic literature, patent filings and public domain information, to long and short-term in-house process development, on an ongoing basis Contribute to our intellectual property portfolio Contribute to Company-wide efforts to promote a safe work environment. Qualifications PhD with 3-8 years or Masters degree with 10-12 years in an industrial upstream process development role. Previous experience with fermentation matrices is strongly preferred. Should have experience handling various bioreactors, adherent and/or suspension cell cultures Knowledge of engineering principles related to scale-up of fermentation processes Culture process development experience such as cell passaging, formulation of media, aseptic technique processing, and managing reagents is a must Ability to thrive in a fast-paced environment Additional Considerations Previous experience in the following areas are all pluses: Working at a start-up or small company. Multi-year industrial fermentation experience with vaccines/biologics is preferred; direct experience with virus-derived recombinant products and/or viral particles is a plus. Familiarity with regulatory requirements for manufacturing vaccines. Authoring or contributing to SOPs. Managing junior engineers, research assistants, and technicians If interested and meet 80% of the criterion connect with us Intelli Search 9071129990 and email profiles@intellisearchonline.net
