Name: Jobpe
Address: T-Hub, Plot No 1/C, Sy No 83/1, Raidurgam panmaktha, Knowledge City Rd, Hyderabad, Telangana, 500081, IN
Telephone: +91-83339-09630
Price range: Free

Structural Biologist Meril

0.0 years

0 Lacs

vapi, gujarat, india

On-site

Job Description: We are seeking a highly skilled and motivated Structural Biologist to join our drug discovery programs. The ideal candidate will bring deep expertise in macromolecular structure determination and modeling, with a focus on elucidating protein structures, analyzing ligand binding, and driving rational drug design in collaboration with computational and medicinal chemistry teams. Key Responsibilities: Analyze protein-ligand interactions to inform medicinal chemistry and lead optimization efforts. Conduct molecular dynamics (MD) simulations and free energy calculations to evaluate complex stability and binding energetics. Apply structural insights to guide hit-to-lead and lead optimization strategies. (Preferred) Utilize machine learning models to support binding site prediction or compound prioritization. Required Skills & Experience: Strong expertise in structural biology techniques, such as crystallography, cryo- EM, or NMR are desirable. Proficient in macromolecular modeling and structure refinement tools (e.g., Phenix, Coot, Chimera, PyMOL). Experience with protein-ligand docking, structure validation, and interaction mapping. Hands-on experience with molecular dynamics simulations using tools such as GROMACS, AMBER, NAMD, or CHARMM. Familiarity with structure-based drug design platforms (e.g., Schrdinger, AutoDock). Scripting or programming experience (Python, R, Bash) for workflow automation and structural data analysis. Preferred Qualifications: Ph.D. in Structural Biology, Biophysics, Computational Biology or related field. Demonstrated experience in drug discovery pipelines, especially in target validation and lead optimization. (Preferred) Background in machine learning or AI applied to biomolecular structure or ligand interaction prediction. Strong publication record or demonstrated project impact in therapeutic development. What We Offer: Work on high-impact, discovery-stage therapeutic programs. Collaborative and interdisciplinary research environment. Access to state-of-the-art computational and structural biology platforms. Show more Show less

Posted 18 hours ago

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Computational Chemist- AI Drug Design Idealcrew Technology

3.0 - 4.0 years

5 - 7 Lacs

pune

Work from Office

To effectively operate and leverage cutting-edge AI-driven drug discovery platforms. Familiarity with machine learning techniques and statistical data analysis. Solid foundation in computational drug discovery methodologies.

Posted Date not available

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