LCMS/MS

1. Position Details

Job Title:

2. Job Purpose

LC-MS/MS system

3. Key Responsibilities

LC-MS/MS Operation

• Operate and monitor LC-MS/MS instruments as per approved SOPs and test methods.
• Perform instrument start-up, shutdown, tuning, calibration, and performance verification.
• Prepare mobile phases, standards, reagents, and samples.
• Carry out sample extraction, cleanup, dilution, and final preparation.
• Create and manage analytical sequences and sample batches.
• Monitor chromatograms, retention time, peak shape, ion ratios, and system suitability.

Method & Analytical Work

• Perform analysis for residues and contaminants such as:
• Antibiotics
• Pesticides
• Veterinary drug residues
• Adultration(SMR,TMR)
• Other chemical contaminants, as applicable
• Review analytical data and identify abnormal or out-of-specification results.
• Perform repeat analysis, investigation, and troubleshooting where required.

Quality & Documentation

• Maintain complete and accurate raw data, worksheets, logbooks, and analytical records.
• Follow

  GLP, GMP, ISO/IEC 17025

  , and applicable laboratory quality requirements.
• Ensure proper documentation of instrument calibration, maintenance, and breakdown records.
• Participate in method validation, verification, recovery studies, precision studies, and measurement uncertainty activities.
• Support internal audits, external audits, and regulatory inspections.

Instrument Maintenance

• Perform routine preventive maintenance of LC-MS/MS and associated equipment.
• Check pumps, autosampler, columns, source cleanliness, gas supply, and vacuum performance.
• Coordinate with service engineers for major maintenance and breakdowns.
• Maintain inventory of columns, solvents, standards, consumables, and spare parts.

4. Educational Qualification

B.Sc. / M.Sc. in Chemistry, Analytical Chemistry, Biotechnology, Food Technology.

5. Experience

• 2–5 years:

  LC-MS/MS Operator / Analyst
• Experience in an

  NABL-accredited laboratory

  will be preferred.
• Experience in food, honey, pharmaceutical, environmental, or residue testing is an advantage.

6. Required Technical Skills

• Hands-on knowledge of

  LC-MS/MS operation

  .
• Knowledge of HPLC/UHPLC systems.
• Understanding of MRM/SRM transitions.
• Knowledge of chromatographic integration and data processing.
• Experience with calibration curves and quantification.
• Knowledge of sample preparation techniques such as

  QuEChERS, SPE, and LLE

  .
• Understanding of method validation and verification.
• Knowledge of system suitability and QC sample requirements.
• Familiarity with laboratory software and instrument data systems.

7. Desired Personal Skills

• Attention to detail and accuracy.
• Good documentation practices.
• Analytical and troubleshooting skills.
• Ability to work independently and in a team.
• Good communication and reporting skills.
• Ability to handle multiple samples and meet testing timelines.

8. Key Performance Indicators (KPI)

• Number of samples analyzed within TAT.
• Accuracy and quality of analytical results.
• Instrument uptime and performance.
• Compliance with SOPs and quality requirements.
• Timely completion of documentation.
• Reduction in repeat analysis and analytical errors.

Benefits:

• Food provided